Journal ArticleDOI
Kongenitale dyserythropoietische Anämien
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This article is published in Deutsche Medizinische Wochenschrift.The article was published on 1970-05-01. It has received 32 citations till now.read more
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Journal ArticleDOI
Advances in the understanding of the congenital dyserythropoietic anaemias.
TL;DR: In this paper, a disease gene has been localized to a chromosomal segment in the three major types of CDA and in CDA type I, the predicted protein structure gives few clues as to its function.
Journal ArticleDOI
Congenital dyserythropoietic anemia type II: epidemiology, clinical appearance, and prognosis based on long-term observation.
Hermann Heimpel,Volker Anselstetter,Ladislav Chrobak,Jonas Denecke,Beate Einsiedler,Kerstin Gallmeier,Antje Griesshammer,Thorsten Marquardt,Gritta Janka-Schaub,Martina Kron,Elisabeth Kohne +10 more
TL;DR: The current recommendation is to consider splenectomy if the anemia compromises patients' performance, and to manage iron overload according to the guidelines derived from patients with thalassemia.
Journal ArticleDOI
Electron and Light Microscopic Study of the Erythroblasts of Patients With Congenital Dyserythropoietic Anemia
TL;DR: The results support the earlier assumption, that this hereditary disorder of erythropoiesis is a disease entity and is not identical with any of the previously described hereditary hematological diseases.
Journal ArticleDOI
Congenital dyserythropoietic anemia type I (CDA I): molecular genetics, clinical appearance, and prognosis based on long-term observation
Hermann Heimpel,Klaus Schwarz,Monika Ebnöther,Jeroen S. Goede,Detlev Heydrich,Torsten Kamp,Lothar Plaumann,Bettina Rath,Jochen Roessler,Otto Schildknecht,Mathias Schmid,Walter A. Wuillemin,Beate Einsiedler,Rosi Leichtle,Hannah Tamary,Elisabeth Kohne +15 more
TL;DR: Twenty-one patients with a confirmed diagnosis of CDA I exhibited chronic macrocytic anemia of variable severity, requiring regular red cell transfusions only in 2 individuals, and fifteen of 16 cases alive at the time of analysis showed mutations of at least one allele from exons 6 to 28 within CDAN1.
Journal ArticleDOI
Congenital dyserythropoietic anaemias: clinical features, haematological morphology and new biochemical data
TL;DR: Three types of congenital dyserythropoietic anaemia were originally identified on the basis of the pattern of dysplastic changes in the erythroblasts and the results of the acidified serum lysis test (Ham test).
Related Papers (5)
Electron and Light Microscopic Study of the Erythroblasts of Patients With Congenital Dyserythropoietic Anemia
Congenital dyserythropoietic anemia with karyorrhexis and multinuclearity of erythroblasts.
H Heimpel,F Wendt +1 more