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Laparoscopic gastric bypass: development of technique, respiratory function, and long-term outcome.

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TLDR
Postoperative lung function was markedly impaired, but there were no beneficial effects of chest physiotherapy, and long-term weight loss after LRYGBP seems to be comparable to what has been reported after open RYGBP.
Abstract
Background: Roux-en-Y gastric bypass (RYGBP) is the preferred operation for the treatment of morbid obesity by many surgeons. Hereby we present the process by which laparoscopic RYGBP (LRYGBP) developed at our institution. Methods: Perioperative morbidity was recorded from 150 consecutive morbidly obese patients operated upon by RYGBP from August 1994 to March 2002. The first 76 consecutive patients have been followed up to 5 years postoperatively. A subgroup of 40 patients was recruited to evaluate the postoperative lung function in a randomized study between receiving and not receiving prophylactic chest physiotherapy. Results: In the whole series, there were 4 conversions to open surgery, 5 leaks, 12 postoperative bleedings and 1 intestinal obstruction. 1 patient succumbed after developing acute dilatation of the bypassed stomach. Respiratory function deteriorated significantly in all patients in the early postoperative period, irrespective if given physiotherapy. During the follow-up period, 3 patients developed mechanical obstruction of the Roux limb. Another patient had a perforated ulcer at the proximal pouch. Weight reduction averaged 70% of excess body weight at 2 years after surgery. Conclusions: LRYGBP is an effective treatment for morbid obesity. During the initial development, we experienced a number of serious complications. The complication rate decreased over time. Postoperative lung function was markedly impaired, but there were no beneficial effects of chest physiotherapy. Long-term weight loss after LRYGBP seems to be comparable to what has been reported after open RYGBP.

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Journal ArticleDOI

Meta-analysis: surgical treatment of obesity.

TL;DR: The increasing numbers of obese individuals have led to intensified interest in surgical treatments to achieve weight loss, and a variety of surgical procedures have been used (Figure 1), which generates weight loss primarily through malabsorption.
Journal ArticleDOI

Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters

TL;DR: Following RYGB and JIB, a pleiotropic endocrine response may contribute to the improved glycemic control, appetite reduction, and long-term changes in body weight.
Journal ArticleDOI

Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial.

TL;DR: A “steering” away from fatty foods after LGBP may be an important mechanism of action in gastric bypass, and energy expenditure developed as expected postoperatively.
Journal ArticleDOI

Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety†

TL;DR: This study investigated prospective changes in gut hormones and metabolic indices after Roux‐en‐$\font\ss=cmss10 scaled 1000 \hbox{\ss Y}$ gastric bypass (RYGB).
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Mechanisms underlying weight loss after bariatric surgery

TL;DR: These mechanisms as well as their mediators are explored in the hope that their in-depth investigation will enable the optimization and individualization of surgical techniques, the development of equally effective but safer nonsurgical weight-loss interventions, and even the understanding of the pathophysiology of obesity itself.
References
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Journal ArticleDOI

Variations in mortality by weight among 750,000 men and women.

TL;DR: The mortality findings of this study match closely those of the Build and Blood Pressure Study 1959 based on the experience of 412 million insured persons.
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Laparoscopic Gastric Bypass, Roux-en-Y: Preliminary Report of Five Cases

TL;DR: The technique of laparoscopic gastric bypass, Roux-en-Y, has been developed, and performed in five patients, showing comparable weight loss, and reduced morbidity and disability.
Journal ArticleDOI

Reduction in Incidence of Diabetes, Hypertension and Lipid Disturbances after Intentional Weight Loss Induced by Bariatric Surgery: the SOS Intervention Study

TL;DR: Intentional weight loss in the obese causes a marked reduction in the 2-year incidence of hypertension, diabetes and some lipid disturbances, and the results suggest that severe obesity can and should be treated.
Journal ArticleDOI

Complications of the laparoscopic Roux-en-Y gastric bypass: 1,040 patients--what have we learned?

TL;DR: The laparoscopic Roux-en-Y gastric bypass for morbid obesity with a totally hand-sewn gastrojejunostomy can be safely performed by the bariatric surgeon with advanced laparoscopically skills in the community setting.
Journal ArticleDOI

Early results of laparoscopic biliopancreatic diversion with duodenal switch: a case series of 40 consecutive patients.

TL;DR: Laroscopic BPD-DS is a complex, yet feasible, procedure resulting in effective weight loss with an acceptable morbidity, and a BMI >65 was associated with increased morbidity and mortality.
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