Patent
Liquid reservoir transdermal patch for the administration of ketorolac
TLDR
In this article, a transdermal patch was proposed for delivering therapeutically effective doses of the drug for a period of 12 hours or more, with a flux rate of 40 μg/cm 2 ·hr or more.Abstract:
The invention is directed to a patch for the transdermal delivery of the racemic form or the active enantiomer of the analgesic ketorolac. The transdermal patch is capable of delivering therapeutically effective doses of the drug for a period of 12 hours or more. The patch is capable of delivering the racemate of ketorolac at a flux rate of 40 μg/cm 2 ·hr or more, and of the active enantiomer at a flux rate of 20 μg/cm 2 ·hr or more.read more
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Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
TL;DR: In this paper, a soluble neutral active hyaluronidase glycoprotein (sHASEGP) was proposed to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies.
Patent
Hepatitis C virus inhibitors
Carol Bachand,Makonen Belema,Deon Daniel H,Andrew C. Good,Goodrich Jason,James Clint A,Lavoie Rico,Lopez Omar D,Alain Martel,Nicholas A. Meanwell,Van N. Nguyen,Jeffrey L. Romine,Ruediger Edward H,Lawrence B. Snyder,Denis R. St. Laurent,Fukang Yang,David R. Langley,Gan Wang,Lawrence G. Hamann +18 more
TL;DR: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection as mentioned in this paper, and also disclosed are pharmaceutical compositions containing such compounds and methods to use these compounds in the treatment.
Patent
Heterocyclic compounds and uses thereof
Alfredo C. Castro,Catherine A. Evans,Somarajannair Janardanannair,Andre Lescarbeau,Tao Liu,Daniel A. Snyder,Martin R. Tremblay,Pingda Ren,Yi Liu,Liansheng Li,Katrina Chan +10 more
TL;DR: In this article, compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activation, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activations are described.
Patent
Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
Oern Almarsson,Magali Bourghol Hickey,Matthew Peterson,Michael J. Zaworotko,Brian Moulton,Nair Rodriguez-Hornedo +5 more
TL;DR: In this article, a pharmaceutical composition comprising a co-crystal of an API and a cocrystal former is defined, where the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester and sulfate ester.
Patent
Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof
TL;DR: In this article, a soluble neutral active hyaluronidase glycoproteins (sHASEGP's) were described and methods of manufacture and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies.
References
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Patent
N[ omega ,( omega -1)-dialkyloxy]- and N-[ omega ,( omega -1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
Deborah A. Eppstein,Philip L. Felgner,Thomas R. Gadek,Gordon Henry Jones,Richard Bolton Roman +4 more
TL;DR: In this article, the same or different compounds of the formula I or an optical isomer thereof are defined, where R1 and R2 are the same and R3, R4 and R5 are different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms and n is a pharmaceutically acceptable anion.
Book
Controlled Release of Biologically Active Agents
TL;DR: Principles of Membrane Diffusion Diffusion- Controlled Systems Biodegradable Systems Osmotic and Mechnical Devices Materials used in Controlled Release Devices Device Preparation and Evaluation Applications and the Future Index are presented.
Patent
Bandage for the administration of drug by controlled metering through microporous materials
TL;DR: A bandage for continuous administration of drugs to the skin or mucosa, comprising a backing member defining one exterior surface, a surface of pressure-sensitive adhesive defining a second exterior surface and disposed therebetween a reservoir containing drug formulation confined therein, is described in this article.
Patent
Transdermal administration of fentanyl and device therefor
TL;DR: Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 μg/cm2 /hr for a substantial portion of their useful life as discussed by the authors.
Patent
Transdermal delivery of pharmaceuticals
TL;DR: In this paper, compositions and methods for the transdermal delivery of pharmacologically active chiral compounds are described which are based on the use of enantiomers or mixtures that contain a disproportionate amount of the enantiomer.