Journal ArticleDOI
Loss of water from heart muscle cells during aging of rats as measured by X-ray microanalysis.
T. Von Zglinicki,G. Lustyik +1 more
TLDR
Comparison of the IWC with TWC of the heart muscle shows that the increase of the volume density of the extracellular space during aging balances the age-dependent loss of myocytes to a certain extent.About:
This article is published in Archives of Gerontology and Geriatrics.The article was published on 1986-12-01. It has received 9 citations till now.read more
Citations
More filters
Journal ArticleDOI
A mitochondrial membrane hypothesis of aging.
TL;DR: A hypothesis is presented here which shows the relation between free radical attack to, and water loss from, the mitochondria and the decreased energy availability in aged cells.
Journal ArticleDOI
Intracellular water and ionic shifts during growth and ageing of rats.
TL;DR: The decrease in intracellular water concentrations in hepatocytes and myocytes during ageing is shown to be solely due to a preferential decrease in the water concentration in mitochondria, which could provide a rationale for a better understanding of functional declines found in mitochondia from old donors.
Journal ArticleDOI
Age-dependent magnetosensitivity of heart muscle hydration.
TL;DR: The results suggest that the hyper magnetos sensitivity of the young heart muscle and the lower sensitivity of older animals are due to initial high and low tissue hydration levels, respectively, and the age‐induced decrease in the magnetosensitivity of heart muscle is likely to be a result of Na+/K+ pump dysfunction.
Journal ArticleDOI
Water Loss in Aging Erythrocytes Provides a Clue to a General Mechanism of Cellular Senescence
TL;DR: Quantitative models are presented indicating that an age-dependent increase in macromolecular crowding resulting from water loss may be responsible for three observed phenomena: a general age- dependent loss of intracellular protein solubility, a delayed and rapid appearance of high molecular weight aggregates, and an age -dependent transfer of intrACEllular protein from dilute to concentrated or condensed phases.
Journal ArticleDOI
Mitochondrial water loss and aging of cells.
References
More filters
Journal ArticleDOI
The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.
TL;DR: An analogous situation existed in the field of protein chemistry during the period after the formulation and confirmation of the Debye—Huckel theory of ionic solutions but before Scatchard's incorporation of the theory into his analysis of the binding properties of proteins.
Journal ArticleDOI
Free radical theory of aging: Consequences of mitochondrial aging
TL;DR: This paper provides plausible explanations, based on mitochondrial aging, of some aging phenomenon: a) the inverse relationship between basal metabolic rate and life span; b) the antioxidants studies thus far which increase the average life span of mice, depress body weight and fail to lengthen maximum life span.
Book
The membrane hypothesis of aging
TL;DR: Experimental results support the “membrane hypothesis” of aging, which shows that cell membranes become more rigid during aging, and a decrease of resting potassium permeability, in brain cells of old rats can be brought about by phytohemagglutinin-P and centrophenoxine.
Journal ArticleDOI
Extracellular space and ionic distribution in rat ventricle
TL;DR: Extracellular space (ECS) of rat ventricle was measured by two independent methods: in vivo tracer and histological procedures in the same tissue and by morphometric analysis of histological preparations fixed in isosmotic glutaraldehyde-saline.
Journal ArticleDOI
The role of membrane structure and function in cellular aging: a review.
TL;DR: Data are presented indicating that some changes in the membrane permeability are also involved in the malignant transformation of the cells; however, these are of opposite direction as compared to aging of cells.