Journal ArticleDOI
Malaria studies in vitro. II. The measurement of drug activities using leucocyte-free blood-dilution cultures of Plasmodium berghei and 3H-leucine.
W. H. G. Richards,S. G. Williams +1 more
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This article is published in Annals of Tropical Medicine and Parasitology.The article was published on 1973-06-01. It has received 13 citations till now. The article focuses on the topics: Plasmodium berghei & Chloroquine.read more
Citations
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Journal Article
Amino acid metabolism and protein synthesis in malarial parasites.
TL;DR: The role of red cell glutathione in the economy of the parasite remains obscure as mentioned in this paper, but it is known that haemoglobin is the main amino acid reservoir available to the intraerythrocytic plasmodium.
Journal ArticleDOI
Studies on Plasmodium falciparum in continuous cultivation. I. The effect of chloroquine and pyrimethamine on parasite growth and viability.
W. H. G. Richards,B. K. Maples +1 more
TL;DR: The activity of two standard antimalarials, chloroquine and pyrimethamine, has been examined in vitro and both showed activity against P. falciparum in vitro in concentrations equivalent to those obtained in plasma levels in vivo.
Book ChapterDOI
Recent Advances in Antimalarial Chemotherapy and Drug Resistance
TL;DR: This chapter discusses recent advancement in antimalarial chemotherapy and drug resistance, with the fact that global malaria eradication has been set back during the past few years and that revised strategy has been necessary.
Journal ArticleDOI
A simple method for separation of uninfected erythrocytes from those infected with Plasmodium berghei and for isolation of artificially released parasites.
TL;DR: Rat erythrocytes infected with Fasmodium berghei were disrupted by gentle passage of Coneanavalin A (ConA) agglutinated cells through a 100 mesh stainless steel grid and the combination of the two techniques produces a high yield of intact free parasites suitable for physiological or immunological studies.
Journal ArticleDOI
The chemotherapy of rodent malaria. XX. Autophagic vacuole formation in Plasmodium berghei in vitro.
TL;DR: In this article, the chemotherapy of rodent malaria was studied in vitro and the autophagic vacuole formation in Plasmodium berghei in vitro was shown to be possible.
References
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Journal ArticleDOI
Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme.
Philip E. Stanley,S.G. Williams +1 more
TL;DR: A simple, economical method is described for determining ATP over the range 10−9 and 10−12 mole, by the firefly luciferin-luciferase system, using any liquid scintillation spectrometer of suitable performance.
Journal ArticleDOI
The Energy Source for Bioluminescence in an Isolated System.
TL;DR: As it is evident that similitudes do preserve the systems'Sk, it follows that the proof of the Theorem of Section 5 is complete.
Journal Article
Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates.
TL;DR: The data establish that the selective action of pyrimethamine in malaria is due to the greater sensitivity to this drug of the plasmodial enzyme as compared to the host enzyme and reflect the unique, potent binding of P. berghei H 2 -folate reductase.
Journal ArticleDOI
Incorporation of Radioactive Precursors into DNA and RNA of Plasmodium knowlesi in vitro
W. E. Gutteridge,P. I. Trigg +1 more
TL;DR: No unambiguous evidence was obtained for any periodicity in the synthesis of DNA or RNA in cultures, even tho cultures remained as synchronous in vitro as they are in vivo, and an estimate is presented of the amount of DNA made during one cycle in vitro.