Journal ArticleDOI
Metabolic interactions between lead and copper in rats ingesting lead acetate
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TLDR
Although Pb ingestion resulted in decreased concentration of Cu in blood and tissue, additional dietary Cu had no effect on Pb levels and can be assumed to be the direct result of a toxic effect of Pb.Abstract:
The effects of Pb ingestion with and without concurrent dietary Cu supplementation were determined on parameters associated with Cu deficiency in rats fed a nutritionally adequate diet. Groups of weanling male Sprague-Dawley rats were fed a purified (AIN-′76) diet and given Pb (0 or 500 ppm) and Cu (0, 6, or 12 ppm) as the acetate salt in deionized drinking water for 5 wk. A Pb-induced Cu deficiency resulted that was characterized by decreased levels of Cu in tissue and blood, decreased activities of the Cu-dependent enzymes, ceruloplasmin (serum) and Superoxide dismutase (erythocytes), and increased concentration of Fe in liver. These effects of Pb were prevented completely or in part by concurrent Cu supplementation. The Pb-induced decrease in hemoglobin and hematocrit values and the decrease in weight gain were not prevented by Cu supplementation of the diet and can therefore be assumed to be the direct result of a toxic effect of Pb. Although Pb ingestion resulted in decreased concentration of Cu in blood and tissue, additional dietary Cu had no effect on Pb levels.read more
Citations
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Lead nephrotoxicity and associated disorders: biochemical mechanisms.
C.V. Nolan,Zahir A. Shaikh +1 more
TL;DR: This review summarizes the biochemical effects of lead on the kidney to understand the mechanisms of lead-induced nephropathy and other associated disorders.
Journal ArticleDOI
Combined effect of tin and lead on heme biosynthesis in rats
TL;DR: Kidneys proved to be the organ in which the highest degree of examined enzyme induction took place, whereas Sn is responsible for induction of heme oxygenase activity in this organ, especially after per os administration.
Journal ArticleDOI
Combined effects of methylmercury, lead, and cadmium on hepatic metallothionein and metal concentrations in the Pekin Duck
TL;DR: Methylmercury, Pb, and their combination elevated hepatic Cu over controls and significantly raised hepatic Zn levels above controls, while the liver content of iron was not significantly altered.
References
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Journal ArticleDOI
Spectrophotometric studies ii. preparations from washed blood cells; nitric oxide hemoglobin and sulfhemoglobin
Journal ArticleDOI
The Possible Significance of the Ferrous Oxidase Activity of Ceruloplasmin in Normal Human Serum
TL;DR: A biological role for the ceruloplasmin of serum in promoting the rate of iron saturation of transferrin and in stimulating iron utilization and the designation of the enzyme as serum ferroxidase is proposed.
Journal ArticleDOI
Superoxide dismutase: a photochemical augmentation assay.
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: A sensitive and convenient augmentation assay for superoxide dismutase has been devised and appears to be remarkably free of interferences and can be applied to crude soluble extracts of biological samples.
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