Journal ArticleDOI
Metabolism of 13-cis-retinoic acid: Identification of 13-cis-retinoyl-and 13-cis-4-oxoretinoyl-β-glucuronides in the bile of vitamin A-normal rats
TLDR
Analysis of the bile by reverse-phase high-pressure liquid chromatography demonstrated that the retinoic acid was being metabolized to several more polar compounds, with a greater proportion of the all-trans-retinoic Acid being converted to compounds that eluted in the more polar regions of the column effluent.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1981-05-01. It has received 25 citations till now. The article focuses on the topics: Retinoic acid & Vitamin.read more
Citations
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Journal ArticleDOI
Comparative teratogenic activities of two retinoids: effects on palate and limb development.
TL;DR: Assessing the relative incidence of readily identifiable malformations of the limb and palate associated with various doses of the two isomers, it was found that 13-cis retinoic acid was four to eight times less embryopathic than all-trans retinoids.
Journal ArticleDOI
Delivery of Retinoid-Based Therapies To Target Tissues †
TL;DR: Evidence that esterification ofretinol and retinol-based drugs within target tissues provides one of the most efficient means to improve the absorption and to reduce the toxicity associated with pharmacological doses of retinoids is reviewed.
Book ChapterDOI
Metabolism of Retinoids
TL;DR: This chapter discusses metabolism of retinoids, which consists of Dietary retinol is quickly esterified in the intestinal mucosa with long-chain fatty acids and is incorporated into chylomicra and transported through the lymph to the liver.
Journal ArticleDOI
13-cis-retinoic acid metabolism in vivo. The major tissue metabolites in the rat have the all-trans configuration.
TL;DR: The data indicate that the isomerization of 13-cis-retinoic acid to all-trans-retinoyl acid and the subsequent conversion toAll-Trans-ret inoyl glucuronide are central events in the in vivo metabolism of 12- cis- Retinoid acid in the rat.
Journal ArticleDOI
All-Trans-Retinoic Acid Pharmacology and Its Impact on the Treatment of Acute Promyelocytic Leukemia
TL;DR: Observed changes in the ATRA dose-response curve in vitro suggest that ATRA resistance is not simply an inability to maintain therapeutic plasma concentrations of drug, but rather may be linked to the intracellular regulation of drug.
References
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Journal ArticleDOI
Tissue changes following deprivation of fat-soluble a vitamin
S. Burt Wolbach,Percy R. Howe +1 more
TL;DR: The specific tissue changes which follow the deprivation of fat-soluble vitamin A in albino white rats and in the human concerns epithelial tissues are described and it is concluded that the deficiency results in loss of specific (chemical) functions of the epitheliums concerned, while the power of growth becomes augmented.
Journal ArticleDOI
Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.
Gary L. Peck,Thomas G. Olsen,Frank W. Yoder,John S. Strauss,Donald T. Downing,Mangala Pandya,Danute Butkus,Jeanne Arnaud-Battandier +7 more
TL;DR: Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy; the mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.
Journal ArticleDOI
APPLICATION OF AN IMPROVED GLUCURONIDASE ASSAY METHOD TO THE STUDY OF HUMAN BLOOD β-GLUCURONIDASE
TL;DR: Previous conditions in which phenolphthalein glucuronide was employed as substrate (1) have proved unsatisfactory for the determination of glucuronidase in plasma, serum, and laked blood cells, but these problems have now been largely overcome by the introduction of a deproteinizing procedure and by otherwise modifying the conditions of assay.
Journal ArticleDOI
Simple device for preparing ethereal diazomethane without resorting to codistillation
Journal ArticleDOI
13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat.
Michael B. Sporn,Robert A. Squire,Charles C. Brown,Joseph M. Smith,Martin L. Wenk,Stephen Springer +5 more
TL;DR: Feeding of the synthetic retinoid, 13-Cis-retinoid acid, inhibited the incidence and extent of bladder cancer in these rats, even when 13-cis- retinoic acid administration was begun after completion of the carcinogen treatment.
Related Papers (5)
Retinoyl Beta-Glucuronic Acid: A Major Metabolite of Vitamin A in Rat Bile
Metabolism in vivo of all-trans-retinoic acid. Biosynthesis of 13-cis-retinoic acid and all-trans- and 13-cis-retinoyl glucuronides in the intestinal mucosa of the rat.
M H Zile,R C Inhorn,H. F. DeLuca +2 more