Patent
Method and composition for photodynamic treatment and detection of tumors
TLDR
In this article, a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole was presented.Abstract:
Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in said cells thereby causing a buildup of protoporphyrin IX in said cells. Also disclosed is a method for the production of protoporphyrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.read more
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Patent
Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
Eric R. Ward,Volrath Sandra +1 more
TL;DR: In this article, eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant plants having altered protox activity which confers tolerance to herbicides are also provided.
Patent
Oligonucleotide compositions with enhanced efficiency
Tod M. Woolf,Margaret F Taylor +1 more
Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.
Patent
Double-stranded oligonucleotides
Todd M. Woolf,Kristin Wiederholt +1 more
TL;DR: In this paper, duplex RNAi compositions, which possess improved properties over those taught in the prior art, are disclosed, and optimized antisense oligomer compositions and method for making and using the both in vitro systems and therapeutically.
Patent
Methods of selecting plants, plant tissue or plant cells resistant to a protoporphyrinogen oxidase inhibitor
Eric R. Ward,Volrath Sandra +1 more
TL;DR: In this paper, the authors provided eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant.
Patent
Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light
TL;DR: An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surfaces with substantially uniform intensity visible light is described in this paper.
References
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Journal ArticleDOI
Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs.
TL;DR: Evaluated data support the view that PDT with topical ALA is a promising approach for the treatment of epidermal cutaneous disorders and a build-up of the porphyrin in the skin.
Patent
Compositions for photodynamic therapy
TL;DR: Porphyrin-type photosensitizers useful in photodynamic therapy can be formulated as water soluble drugs by conjugation of the photoensitizer to a hydrophilic polymer.
Patent
New tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
Bommer Jerry C,Burnham Bruce F +1 more
TL;DR: In this article, a new therapeutic composition which is useful in photodiagnosis and phototherapy, especially in the detection and treatment of tumors and cancerous tissues in the human or animal body was proposed.
Patent
Δ2 -1,2,4-triazolin-5-one derivatives and herbicidal usage thereof
TL;DR: A novel Δ2 -1,2,4-triazolin-5-one derivative having a herbicidal activity is represented by the formula ##STR1## in this article.
Journal Article
Selective in vivo tumor localization of uroporphyrin isomer I in mouse mammary carcinoma: superiority over other porphyrins in a comparative study.
TL;DR: It is concluded that the greater specificity of tumor uptake by UROP I and its lack of retention by gut mucosa warrants further study to determine its potential clinical application as a diagnostic marker, particularly for early mucosal cancer, and in photoradiation therapy.
Related Papers (5)
Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
Eric R. Ward,Volrath Sandra +1 more