FMC Corporation

About: FMC Corporation is a company organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Alkyl & Hydrogen peroxide. The organization has 4783 authors who have published 5707 publications receiving 66245 citations.

Adaptive Noise Smoothing Filter for Images with Signal-Dependent Noise

Abstract: In this paper, we consider the restoration of images with signal-dependent noise. The filter is noise smoothing and adapts to local changes in image statistics based on a nonstationary mean, nonstationary variance (NMNV) image model. For images degraded by a class of uncorrelated, signal-dependent noise without blur, the adaptive noise smoothing filter becomes a point processor and is similar to Lee's local statistics algorithm [16]. The filter is able to adapt itself to the nonstationary local image statistics in the presence of different types of signal-dependent noise. For multiplicative noise, the adaptive noise smoothing filter is a systematic derivation of Lee's algorithm with some extensions that allow different estimators for the local image variance. The advantage of the derivation is its easy extension to deal with various types of signal-dependent noise. Film-grain and Poisson signal-dependent restoration problems are also considered as examples. All the nonstationary image statistical parameters needed for the filter can be estimated from the noisy image and no a priori information about the original image is required.

Adaptive restoration of images with speckle

Abstract: Speckle is a granular noise that inherently exists in all types of coherent imaging systems. The presence of speckle in an image reduces the resolution of the image and the detectability of the target. Many speckle reduction algorithms assume speckle noise is multiplicative. We instead model the speckle according to the exact physical process of coherent image formation. Thus, the model includes signal-dependent effects and accurately represents the higher order statistical properties of speckle that are important to the restoration procedure. Various adaptive restoration filters for intensity speckle images are derived based on different model assumptions and a nonstationary image model. These filters respond adaptively to the signal-dependent speckle noise and the nonstationary statistics of the original image.

Drug interactions with grapefruit juice

Abstract: Some drugs demonstrate a significantly greater (up to 3-fold) mean oral bioavailability on coadministration with grapefruit juice. With some calcium antagonists, the benzodiazepines midazolam and triazolam and the antihistamine terfenadine, changes in bioavailability are accompanied by altered drug action. Study design factors possibly contribute to the magnitude of changes in drug bioavailability; they include the source of the citrus, its intake schedule, drug formulations and individual metabolising capacity. The components of citrus juice that are responsible for clinical drug interactions have yet to be fully determined. Based on the flavonoid naringin's unique distribution in the plant kingdom, abundance in grapefruit and ability to inhibit metabolic enzymes, naringin is likely to be one of the grapefruit components influencing drug metabolism. Other components present in citrus fruit, such as furanocoumarins, may be more potent inhibitors than flavonoids and are under investigation. Conclusions drawn from clinical drug interaction studies should be considered specific to the citrus fruit products evaluated because of the variation in their natural product content. The predominant mechanism for enhanced bioavailability is presumably the inhibition of oxidative drug metabolism in the small intestine. The consistent findings across studies of diverse cytochrome P450 (CYP) 3A substrates support the mechanistic hypothesis that 1 or more grapefruit juice components inhibit CYP3A enzymes in the gastrointestinal tract. The evaluation of the need to avoid the concomitant intake of grapefruit products with drugs is best done on an individual drug basis rather than collectively by drug class. Based on the narrow therapeutic range of cyclosporin and research experience in organ transplant recipients, its interaction with grapefruit juice is likely to be clinically significant.