Patent
Method for the preparation of binding molecules
TLDR
In this paper, a genetically engineered organism displaying the expression product of an inserted gene on its outer surface was presented, in a preferred embodiment, a single chain antibody was displayed on the outer surface of the genetically engineered microorganism.Abstract:
This invention comprises a genetically engineered organism displaying the expression product of an inserted gene on its outer surface. In a preferred embodiment, a single chain antibody is displayed on the outer surface of the genetically engineered microorganism.read more
Citations
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Patent
Single polypeptide chain binding molecules
TL;DR: In this article, a single polypeptide chain binding molecule has been proposed which has binding specificity and affinity substantially similar to the binding specificity of the light and heavy chain aggregate variable region of an antibody.
Patent
Directed evolution of novel binding proteins
Robert Charles Ladner,Sonia Kosow Guterman,Bruce L. Roberts,William Markland,Arthur C. Ley,Rachel Baribault Kent +5 more
TL;DR: In this article, a structural signal called for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) is introduced into a genetic package.
Patent
Production of chimeric antibodies - a combinatorial approach
Hendricus Renerus Jacobus Matteus Hoogenboom,Michael Baier,Laurent Stephane Anne Therese Jespers,Gregory Paul Winter +3 more
TL;DR: In this paper, the authors describe methods for the production of antibodies, or antibody fragments, which have the same binding specificity as a parent antibody, but which have increased human characteristics.
Patent
Recombinant library screening methods
TL;DR: In this paper, DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vector, or into a sequence encoding a protein which may be linked by means of a ligand to a phage coat protein.
Patent
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
Andrew David Griffiths,Hoogenboom Hendricus R J M,James D. Marks,John Mccafferty,Gregory Paul Winter,Geoffrey Walter Grigg +5 more
TL;DR: In this paper, the authors described methods for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species.
References
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Patent
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
TL;DR: In this paper, a computer-based system and method for determining and displaying possible chemical structures for converting two naturally aggregated but chemically separated polypeptide chains into a single polypeptic chain which will fold into a three dimensional structure very similar to the original structure made of the two poly peptide chains.
Patent
Modified vaccinia virus
Enzo Paoletti,Dennis Panicali +1 more
TL;DR: In this paper, the authors described methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods.
Patent
Viruses with recombinant surface proteins.
TL;DR: In this paper, foreign protein segments having specific medically or commercially useful biological functions are incorporated in surface proteins of viruses, and the viruses with the incorporated protein segments are convenient agents for introducing the protein segments into animals such as humans, and are thus useful as vaccines.