Patent
Method of relieving pain and treating inflammatory conditions in warm-blooded animals
Tiberio Bruzzese,Rodolfo Ferrari +1 more
TLDR
In this article, a method for relieving pain and treating inflammatory conditions in warm-blooded animals, including humans, is described. But this method is not suitable for the treatment of inflammatory conditions.Abstract:
The present invention provides a method of relieving pain and of treating inflammatory conditions in warm-blooded animals, including humans, which comprises administering to a warm-blooded animal suffering from an inflammatory condition a phenyl-alkanoic acid salt of the general formula: ##STR1## wherein R 1 is a hydrogen atom or a methyl radical, R 2 is a halogen atom or an alkyl radical containing up to 5 carbon atoms, which may be straight-chained or branched, for example an isobutyl radical, or is a cyclohexyl radical or is a phenoxy or benzoyl radical, which may be substituted by one or two halogen atoms, R 3 is a hydrogen atom or an allyloxy radical or R 2 and R 3 , together with the phenyl nucleus to which they are attached, represent a naphthyl ring system containing a methoxy substituent, B is a primary, secondary or tertiary amino group or a guanidino or amidino group and n is a whole number not greater than 5, for example B is an amino group and n is 3 (ornithine), B is an amino group and n is 4 (lysine) or B is a guanidino radical and n is 3 (arginine).read more
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Patent
Modified release dosage form
TL;DR: In this paper, the authors proposed a dosage form comprising at least one active ingredient, and first core and second core surrounded by and separated by a shell, which provided a delay of at least 1 hour between the initial release of active ingredient contained in said first core, and the subsequent release of the active ingredient containing in said second core after contacting of the dosage form with a liquid medium.
Patent
Immediate release dosage form comprising shell having openings therein
TL;DR: In this article, an immediate release dosage form having a solid core and a shell readily soluble in gastrointestinal fluids was proposed. But this dosage form also comprises one or more openings in the shell.
Patent
S(+)-ibuprofen-L-amino acid and S(+)-ibuprofen-D-amino acid as onset-hastened enhanced analgesics
TL;DR: S(+)-ibuprofen-L-amino acids and S(+)ibupron-Damino acid stereoisomers give an onset-hastened, enhanced analgesic response in humans as discussed by the authors.
Journal ArticleDOI
Spray drying of poorly soluble drugs from aqueous arginine solution.
TL;DR: The formation of co-amorphous salts led to improved dissolution characteristics when compared to the corresponding physical mixtures or to pure crystalline drugs, and strong interactions revealed strong interactions that account for the positive deviation between measured and estimated Tg values.
Journal ArticleDOI
Dissolution Methods to Increasing Discriminatory Power of In Vitro Dissolution Testing for Ibuprofen Free Acid and Its Salts.
TL;DR: The effect of buffer concentration media was investigated as a possible approach to ensuring the discriminative capacity of the in vitro dissolution methods and it was possible to account for differences in disintegration in a more physiologically relevant way and thus to better reflect the in-vivo performance of the various formulations.
References
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Patent
Substituted biphenyl acetic acid derivatives
TL;DR: In this article, substituted biphenyl acetic acids and derivatives thereof are used as antiinflammatory agents and for the control of arthritic conditions, which are useful as anti inflammatory agents and anti-arthritic conditions.
Patent
Preparation of optical isomers of arylalkylacetic acids
TL;DR: In this paper, the A-SUBSTITUTed ARYLACETIC ACIDS are used as ANTI-INFLAMMATORY, ANALGESIS, ANTIPYRETIC and ANTIPRUTITIC AGENTS.
Patent
Anti-Inflammatory Agents
TL;DR: In this paper, the authors proposed a general formula for compounds of general formula where R1 represents cycloalkyloxy (C3-C5), cyclo-alkyloxyphenyl acetic acid is prepared by hydrogenation of the allyloxy and but-2-enyloxy compounds by reaction with cyclopentyl iodide.
Patent
Tetrahydronaphthylalkanoic acids and their derivatives
Julius Diamond,George H. Douglas +1 more
TL;DR: In this article, novel tetrahydronaphthylalkanoic acids and their derivatives are described and their compositions and method of treatment of inflammation is also disclosed; however, the authors do not discuss the use of these acids in medical applications.