Journal ArticleDOI
Microwave‐assisted from synthesis of 2‐arylamino‐2‐imidazolines on a solid support
Murat Genc,Süleyman Servi +1 more
TLDR
In this article, an efficient synthesis of 2-arylamino-2-imidazolines from dimethyl N-aryldithioimidocarbonates and ethylenediamine on solid support under microwave irradiation has been developed.Abstract:
An efficient synthesis of 2-arylamino-2-imidazolines from dimethyl N-aryldithioimidocarbonates and ethylenediamine on solid support under microwave irradiation has been developed. The reaction time has been reduced from hours to minutes with improved yields as compared to conventional heating. Their piperidin-4-ylmethyl and morpholin-4-ylmethyl derivatives were synthesized by treatment with formaldehyde and piperidine or morpholine. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:142–222, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20081read more
Citations
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Journal ArticleDOI
Combinatorial Syntheses of Five-Membered Ring Heterocycles Using Carbon Disulfide and a Solid Support
Young-Dae Gong,Tae-Ho Lee +1 more
TL;DR: The utility of carbon disulfide and a solid support as starting materials for the synthesis of diverse, drug-like, five-membered ring heterocycles and their fused counterparts is covered.
Book ChapterDOI
Five-Membered Heterocycles
TL;DR: In this paper, the chemistry, structural and reactivity aspects of saturated, unsaturated five membered monocyclic and benzene fused heterocycles with mono nitrogen, oxygen and sulfur heteroatom such as pyrrole, pyrrolidine, indole, isoindole, indolizine, carbazole, furan, reduced furan.
Journal ArticleDOI
Synthetic routes toward 2-substituted 2-imidazolines
TL;DR: Methods for the synthesis of 2-substituted 2-imidazolines are reviewed in this paper, where the authors describe techniques that provide multiple points of diversity, making them especially useful in library development for this pharmacologically important class of compounds.
Journal ArticleDOI
Synthesis, spectral characterization and biological studies of transition metal(II) complexes with triazole Schiff bases: Synthesis, triazole Schiff bases, metal complexes, biological activity
Muhammad Hanif,Zahid H. Chohan +1 more
TL;DR: In this article, a metal-based triazoles (1-12) were synthesized by the interaction of novel Schiff base ligands (L1-L3) with the Co(II), Ni-II, Cu(II) and Zn-II metal ions using various physical, analytical and spectroscopic techniques.
Journal ArticleDOI
Investigation of Antioxidant Vitamins (A, E, C) and Lipid Peroxidation Levels in Rats Injected N-(1,3-Benzothiazol-2-yl)-N-(4,5-dihydro-1H-imidazol-2-yl) amine
TL;DR: It can be suggested that 2-Amdz induced a severe stress and more importantly, increased the amount of free radicals and significantly decreased the levels of serum antioxidant vitamins.
References
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A tentative rationalization of microwave effects in organic synthesis according to the reaction medium, and mechanistic considerations
Laurence Perreux,André Loupy +1 more
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Solvent-free microwave organic synthesis as an efficient procedure for green chemistry
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Journal ArticleDOI
Nuclear magnetic resonance spectroscopy. XIII. Amidines. VII. Proton and carbon-13 nuclear magnetic resonance studies on the tautomerism, geometrical isomerism, and conformation of some cyclic amidines, guanidines, and related systems
Lloyd M. Jackman,Timothy Y Jen +1 more
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New aromatic iminoimidazolidine derivatives as α1-adrenoceptor antagonists: A novel synthetic approach and pharmacological activity
TL;DR: The results indicate that, even though some discrepancies are observed in terms of the alpha1 subtype targeted by this new family of compounds, they show an interesting profile as antagonists of alpha1-adrenoceptors and a new prototype, compound 1a, has been found deserving further development.
Journal ArticleDOI
Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin.
TL;DR: The most promising compound, 5-(3-chlorobenzylidene)-2-(isonicotinoylhydrazino)-imidazoline-4-one, with activity in vitro comparable with rifampin, was tested in vivo in the animal tuberculosis model but none of them demonstrated satisfactory activity.