Journal ArticleDOI
Mitochondrial DNA. II. Structure and physicochemical properties of isolated DNA.
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TLDR
The molecular topology and proportions of the DNA forms isolated from mitochondria of mouse fibroblasts (L-cells) were studied after removal of contaminating nuclear DNA by DNase, and the closed circular DNA component of L-cell mitochondria (DNA I) was isolated and studied with respect to the number of tertiary turns and its resistance to denaturation by alkali and heat.About:
This article is published in Journal of Molecular Biology.The article was published on 1969-06-28. It has received 79 citations till now. The article focuses on the topics: Mitochondrial DNA & Nuclear DNA.read more
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Progress in Molecular and Subcellular Biology
TL;DR: This volume summarizes the current knowledge of the interferon-based natural antiviral protection system, including 2',5'-oligoadenylate and double-stranded RNA, to help to develop a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.
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Mitochondrial DNA. I. Intramitochondrial distribution and structural relations of single- and double-length circular DNA.
TL;DR: The observed membrane associations and the multiplicity of DNA molecules per mitochondrialrion or per nucleoid may be related to mitochondrial duplication; the high degree of variation in number of molecules per mitochondrion implies redundancy of informational content.
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How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue
TL;DR: Novel applications of mtDNA as a biomarker of UVR-induced oxidative stress will also be highlighted in this review, as ultraviolet radiation-induced gene mutations play a key role in the development of skin cancer and ageing in human skin.
References
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Journal ArticleDOI
Selective extraction of polyoma DNA from infected mouse cell cultures.
Journal ArticleDOI
Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.
J. Marmur,Paul Doty +1 more
TL;DR: The previously discovered linear relation between the base composition of DNA, expressed in percentage of guanine plus cytosine bases, and the denaturation temperature, T m, has been further investigated and it appears that the measurement of the T m is a satisfactory means of determining base composition in DNA.
Journal ArticleDOI
A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization.
J.-B. Lepecq,Claude Paoletti +1 more
TL;DR: Evidence is presented that formation of this complex (complex I) is specific for base-paired regions either in DNA, RNA or RNA: DNA hybrids, and that the basis of this specificity is intercalation of the dye between base pairs.
Journal ArticleDOI
Determination of the base composition of deoxyribonucleic acid from its buoyant density in CsCl.
TL;DR: A comprehensive study of the buoyant density of DNA as a function of composition has been made and the linear relation previously reported has been confirmed.
Related Papers (5)
Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes
David A. Clayton,Jerome Vinograd +1 more