Showing papers in "Cell in 1982"

TL;DR: During cell transformation and tumor devel- opment this cell type specificity of intermediate filaments is largely conserved’ and classification of tumors by their specific type of intermediate Filaments has re- cently become very valuable in clinical histodiagnosis.

TL;DR: Using SDS-polyacrylamide gel electrophoresis of intact collagen chains and two-dimensional cyanogen bromide peptide mapping, this work demonstrated a complete return to the differentiated collagen phenotype and demonstrates a reversible system for the study of gene expression.

TL;DR: It is proposed that the IVS portion of the RNA has several enzyme-like properties that enable it to break and reform phosphodiester bonds and that enzymes, small nuclear RNAs and folding of the pre-rRNA into an RNP are unnecessary for these reactions.

TL;DR: It is proposed that tumorigenesis by MMTV is strongly favored by proviral insertion within the int1 locus, perhaps as a consequence of enhanced expression of a novel cellular oncogene.

TL;DR: The Xenopus embryo undergoes 12 rapid synchronous cleavages followed by a period of slower asynchronous divisions more typical of somatic cells, termed the midblastula transition (MBT), which shows that at the MBT the blastomeres become motile and transcriptionally active for the first time.

TL;DR: Duck hepatitis B virus, a DNA virus closely related to human hepatitis Birus, was studied in infected duck liver and a pathway for the replication of the DNA genome of hepatitis B-like viruses by reverse transcription of an RNA intermediate is proposed.

TL;DR: A model is proposed to account for the synthesis and regulation of the two forms of inverts: the larger, regulated mRNA contains the initiation codon for the signal sequence required for synthesis of the secreted, glycosylated form of invertase; the smaller, constitutively transcribed mRNA begins within the coding region of the signal sequences, resulting in synthesis ofThe intracellular enzyme.

TL;DR: It is shown here that a plasmid containing a cloned gene coding for a yeast leucine tRNA comes under developmental control when injected into cleaving eggs, suggesting that the MBT is triggered by the DNA through titration of suppressor components present in the egg.

TL;DR: An operational antigenic map of the hemagglutinin of influenza virus A/PR/8/34 indicates the presence of five immunodominant antigenic regions exhibiting various degrees of operational linkage.

TL;DR: It seems that the upstream element of the hsp 70 promoter is analogous to that of other promoters, but is only functional in heat-shocked cells.

TL;DR: A consensus sequence is uncovered between the region deleted in cyc1-512 and the 3' nontranslated regions of some but not all yeast genes, and the possible role of this sequence in transcription termination is discussed.

TL;DR: The fact that the adenovirus and Sv40 tumor antigens, both required for transformation, can be found in physical association with the same cellular protein in a transformed cell is a good indication that these two diverse viral proteins share some common mechanisms or functions.

TL;DR: The oncogene appears to have undergone little, if any, amplification in several bladder carcinoma cell lines and is unrelated to transforming sequences detected in a variety of other types of human tumor cell lines derived from colonic and lung carcinoma and from neuroblastoma.

TL;DR: These results suggest that the immunogenicity of an intact protein molecule is not the sum of the immunogeneicity of its pieces.

TL;DR: The expression of specific keratin classes appeared to correlate with different types of epithelial differentiation (simple versus stratified; keratinized versus nonkeratinized).

TL;DR: A method is described for the production of a highly purified and homogeneous population of adherent bone marrow-derived macrophages that are devoid of CSF-1-producing cells, and the method may also be used to obtain nonadherent precursors of the mononuclear phagocytic series.

TL;DR: A gene (MF alpha) coding for alpha-factor, a tridecapeptide mating factor secreted by yeast alpha cells, was cloned and sequenced in this paper.

TL;DR: Results indicate that endocytic vesicles become acidic prior to fusion with lysosomes, as measured by the pH changes in the microenvironment of internalized ligands following receptor-mediated endocytosis.

TL;DR: Using lacl-Z fusion strains of Escherichia coli, systems that detect deletions of varying lengths are devised and possible mechanisms of deletion formation are discussed and its relationship to the excision of transposable elements is considered.

TL;DR: The fact that yeast can recognize and use DNA ends from the distantly related organism Tetrahymena suggests that the structural features required for telomere replication and resolution have been highly conserved in evolution.

TL;DR: Results suggest that vacuolar and secretory glycoproteins require the same cellular functions for transport from the endoplasmic reticulum and from the Golgi body.

TL;DR: Observations that P elements are present in 30-50 copies per haploid genome in all P strains examined and apparently are missing entirely from all M strains examined strongly support the P factor hypothesis for the mechanistic basis of P-M hybrid dysgenesis.

TL;DR: Partial proteolysis of the nucleoplasmin pentamer reveals two structural domains within each subunit: a relatively exposed "tail" and a protected "core" that are sufficient for selective accumulation.

TL;DR: The design of the HSV amplicon system is based on the previous observation that cotransfection of cells with helper virus DNA and seed monomeric repeat units of HSV defective genomes results in the regeneration of concatemeric defective genomes composed of multiple reiterations of the seed repeats.

TL;DR: It is shown that production of HSP 70 (the major heat-induced protein in these cells) is quantitatively correlated with the degree of stress, and evidence is presented that indicates that the same quantity of H SP 70 is required to release the block in normal protein synthesis.

TL;DR: Two-dimensional gel electrophoresis, peptide mapping and immunoprecipitation tests showed that the 40-55 kd mesothelial proteins are a family of keratins distinct in size, charge or peptide map from the "epidermal ker atins" synthesized by cultured keratinocytes.

TL;DR: Evidence is provided for a direct linkage between antigen recognition by T lymphocytes and surface expression of the T3 molecular complex, which inhibits cytotoxic T lymphocyte effector function by T4 and T8 clones as well as antigen-specific T cell recognition.