Journal ArticleDOI
Mode of operation and performance characteristics of microbore columns for use in liquid chromatography
R.P.W. Scott,P. Kucera +1 more
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TLDR
In this paper, the production and operating characteristics of microbore columns are described and details of the modification of the LDC UV monitor to give the necessary low dead volume detection cell for use with such columns are given.About:
This article is published in Journal of Chromatography A.The article was published on 1979-02-01. It has received 255 citations till now. The article focuses on the topics: Theoretical plate.read more
Citations
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Journal ArticleDOI
Some reflections on speed and efficiency of modern chromatographic methods
TL;DR: In this article, the authors compare various techniques in terms of attainable efficiency and speed as well as of the demands on the detectors, and some speculations on future proliferation will be given.
Journal ArticleDOI
Implementations of two-dimensional liquid chromatography.
Georges Guiochon,Nicola Marchetti,Nicola Marchetti,Khaled S. Mriziq,Khaled S. Mriziq,R. Andrew Shalliker +5 more
TL;DR: It is suggested that the combination LC(x)xLC(t) shows exceptional promise because it permits the simultaneous second-dimension separations of all the fractions separated in the first-dimension, thus providing remarkable time saving.
Journal ArticleDOI
Use of light scattering as a detector principle in liquid chromatography
TL;DR: In this paper, the authors describe a detector based on the large difference between the vapour pressure of solvents commonly used in liquid chromatography and that of most analytes, which thus permits phase separation between them.
Journal ArticleDOI
Microcolumn liquid chromatography: Instrumentation, detection and applications
TL;DR: The potential of hyphenation of microcolumn liquid chromatography with other techniques, more particularly of multidimensional chromatography and microcolumn LC coupled to mass spectrometry is reviewed in this paper.
Journal ArticleDOI
Recent developments in microcolumn liquid chromatography
TL;DR: The emphasis of this review is on miniaturized sample clean-up, sample introduction techniques and on both established and more recent detection techniques for microcolumn LC.
References
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Journal ArticleDOI
A study of micro-high-performance liquid chromatography
TL;DR: Several technical problems such as the following have been solved in order to perform micro-high-performance liquid chromatography (MHPLC): (1) a method for packing a narrow column with stationary phase and selection of suitable column material; (2) preparation of micro-flow cells suitable for a micro-column; (3) improvement of the detector system; (4) methods for the pressurized passage of mobile phase at low flow-rates and for injection of a micro amount of sample solution; and (5) gradient elution methods suitable for microcolumns as mentioned in this paper.
Journal ArticleDOI
Sampling and extra-column effects in high-performance liquid chromatography; influence of peak skew on plate count calculations.
TL;DR: Computer simulation studies demonstrated that serious errors can result from calculating column plate count with non-Gaussian peaks and the maximum allowable peak tailing is suggested and a new method for quantitating peak skew is proposed.
Journal ArticleDOI
High-performance liquid chromatography on small particle silica gel.
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