Book ChapterDOI
Modulation of Learning and Memory: Effects of Drugs Influencing Neurotransmitters
Bruce E. Hunter,Steven F. Zornetzer,Murray E. Jarvik,James L. McGaugh +3 more
- pp 531-577
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TLDR
Drugs have been utilized for many years as experimental tools in the analysis of the biological mechanisms underlying behavior and an assessment of the actions of various drugs on behavior, coupled with knowledge of mechanisms of drug action are assumed.Abstract:
Drugs have been utilized for many years as experimental tools in the analysis of the biological mechanisms underlying behavior. An assumption implicit in this approach is that an assessment of the actions of various drugs on behavior, coupled with knowledge of mechanisms of drug action, will provide important information concerning the neurobiological bases of behavior.read more
Citations
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Journal ArticleDOI
Nicotinic systems and cognitive function.
TL;DR: Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine, and nicotine may prove to be useful therapeutic treatment for this and other types of dementia.
Journal ArticleDOI
Reticulo-cortical activity and behavior: A critique of the arousal theory and a new synthesis
TL;DR: The fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior.
Journal ArticleDOI
The Pharmacology of Memory: A Neurobiological Perspective
Larry R. Squire,Hasker P. Davis +1 more
TL;DR: Drugs can be viewed as tools to dissect the neural machinery involved in memory and to reveal as much as possible about the neurotransmitter systems and biochemical steps involved, such as how memory changes over time and how many processes are involved.
Journal ArticleDOI
Cholinergic receptor blockade impairs spatial localization by use of distal cues in the rat.
TL;DR: The results support the idea that central cholinergic systems are important for spatial mapping, which demands the use of distal visual cues, but not for spatial localization, which requires other search strategies and possibly the useof proximal tactile, kinesthetic, and visual cues.
References
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Book
The pharmacological basis of therapeutics
TL;DR: In this article, 42 authors share the herculean task of reviewing the flood of recent literature on pharmacology and rational use of drugs, under single or dual authorship they contribute the 76 chapters in the 18 sections.
Journal ArticleDOI
Brain stem reticular formation and activation of the EEG
G. Moruzzi,Horace W. Magoun +1 more
TL;DR: In this paper, it was shown that reticular activation is associated with the activation of the reticular formation of the brain stem, and that reticulus activation can be induced by low frequency stimulation of the diffuse thalamic projection system, rather than intra-cortical spread following the arrival of afferent impulses at the sensory receiving areas of the cortex.
Book
The Biochemical Basis of Neuropharmacology
TL;DR: The fifth edition of the book as discussed by the authors contains two new chapters on topics of current interest: molecular neurobiology and neuromodulation, as well as all other chapters have been updated.
Related Papers (5)
Human serial learning: enhancement with arecholine and choline impairment with scopolamine
Selective loss of central cholinergic neurons in alzheimer's disease
Peter Davies,A.J.F. Maloney +1 more