Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain
Walter Stühmer,J. P. Ruppersberg,Klaus-Hasso Schro̊ter,Bert Sakmann,M. Stocker,Karl Peter Giese,A. Perschke,A. Baumann,Olaf Pongs +8 more
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TLDR
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins, which suggest the molecular basis for the diversity of voltage‐gated K+ channels in mammalian brain is based on the expression of several RCK proteins by a family of genes.Abstract:
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.read more
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References
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