Open AccessJournal Article
Molecular Imaging: Editorial overview
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Chang et al. as mentioned in this paper describe the development and application of new approaches to study molecular-level events in biological systems, which has attracted a broad base of researchers with diverse backgrounds spanning chemistry, physics, biology, medicine, and engineering.About:
This article is published in Current Opinion in Chemical Biology.The article was published on 2010-01-01 and is currently open access. It has received 103 citations till now. The article focuses on the topics: Molecular imaging.read more
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How were new medicines discovered
David C. Swinney,Jason Anthony +1 more
TL;DR: It is postulate that a target-centric approach for first-in-class drugs, without consideration of an optimal MMOA, may contribute to the current high attrition rates and low productivity in pharmaceutical research and development.
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Medicinal attributes of 1,2,3-triazoles: Current developments
TL;DR: The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors, HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.
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New and classic families of secreted fungal heme peroxidases
TL;DR: This review focuses on the most recently discovered and novel types of heme-dependent peroxidases, aromatic peroxygenases (APOs), and dye-decolorizing peroxIDases (DyPs), which catalyze remarkable reactions such as peroxide-driven oxygen transfer and cleavage of anthraquinone derivatives, respectively.
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Lipase promiscuity and its biochemical applications
Manali Kapoor,Munishwar N. Gupta +1 more
TL;DR: This review attempts to recast the known information on specificity of lipases in the context of enzyme promiscuity and the beneficial consequences of this promiscuous behavior in biotechnology sectors are discussed.
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Photon-upconverting nanoparticles for optical encoding and multiplexing of cells, biomolecules, and microspheres.
Hans H. Gorris,Otto S. Wolfbeis +1 more
TL;DR: This Review highlights the potential of UCNPs for labeling and encoding biomolecules, microspheres, and even whole cells and lays the foundation for highly multiplexed analyte detection.