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Journal ArticleDOI

Multiple myeloma with new bone formation.

Philip Krainin, +2 more
- 01 Dec 1949 - 
- Vol. 84, Iss: 6, pp 976-982
TLDR
The case to be presented is of unusual interest because it has been possible to present a typical and characteristic lesion of bone in multiple myeloma that is a discrete osteolytic involvement.
Abstract
THERE that the typical and characteristic lesion of bone in multiple myeloma is a discrete osteolytic involvement. The roentgenographic appearance is usually that of a punched-out area with sharp margination and without evidence of surrounding productive reaction. In a description of multiple myeloma Boyd 1 stated, "It is a pure rarefying lesion with no formation of new bone." To quote Geschichter 2 : "The widespread occurrence of small, sharply demarcated defects in the marrow cavity, unaccompanied by bending deformity or the formation of new bone, are the cardinal features in the diagnosis of multiple myeloma." Snapper 3 affirmed that in multiple myeloma "no new formation of bone takes place." Shanks, Kerley and Twining 4 declared categorically concerning the osseous lesions of multiple myeloma that "they are entirely osteolytic, and never give rise to new bone formation." The case to be presented is of unusual interest because it has been possible to

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Citations
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Plasma-cell myeloma. II. Clinical aspects.

TL;DR: Pathologic Proteinuria and Renal Insufficiency Impairment of renal function, characterized by nitrogen retention in the absence of hypertension, occurs in over 50 per cent of cases of plasma-cell m...
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The neuropathy of multiple myeloma

TL;DR: In this paper, the authors introduce the concept of peripheral myelomatous paraplegia, which is only obscurely related to multiple mycloma, for the disease does not in any way depend on compression of nervous structures by tumour tissue.
Journal ArticleDOI

Neurologic Complications of Myelomatosis

TL;DR: The neurologic complications observed in 277 patients admitted to a general hospital, where a diagnosis of multiple myeloma was eventually proved, are reported and discussed.
Journal ArticleDOI

Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma.

TL;DR: Quantitative histologic analysis of two sural nerves biopsied within 2 years of each other during the course of the disease indicated that both large and small myelinated fibers degenerated progressively, with relative preservation of unmyelination fibers.
Journal ArticleDOI

The relation between chronic polyneuropathy and osteosclerotic myeloma.

TL;DR: Observations indicate that if the myeloma can be controlled, this otherwise fatal neuropathy is reversible, and this concurrence is significant.
References
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Book

A text-book of x-ray diagnosis,

TL;DR: Volume IV of the fourth edition of A Text-Book of X-Ray Diagnosis represents a departure in policy for this well-known text; the Alimentary Tract has been removed from the volume on the Abdomen and now appears by itself.
Journal ArticleDOI

Multiple myeloma: Its clinical and laboratory diagnosis with emphasis on electrophoretic abnormalities

TL;DR: An analysis of sixty-one cases of plasma cell tumors is given and suggestions are made which may increase the accuracy and promptness of the diagnosis of this type of tumor.
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