Journal ArticleDOI
Multiple tachykinins (neurokinin A, neuropeptide K and substance P) in capsaicin-sensitive sensory neurons in the guinea-pig
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TLDR
It is concluded that multiple tachykinins, including SP, NKA, NPK and an ELE-like peptide, are present in capsaicin-sensitive sensory nerves in the guinea-pig.About:
This article is published in Regulatory Peptides.The article was published on 1985-12-01. It has received 280 citations till now. The article focuses on the topics: Neuropeptide K & Neurokinin A.read more
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Local effector functions of capsaicin-sensitive sensory nerve endings : involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
TL;DR: Etude du mecanisme d'action des neurones sensoriels et des fonctions de leurs effecteurs locaux en reponse a differents stimuli, au niveau des tissus directement en contact avec l'environnement exterieur.
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The sensory-efferent function of capsaicin-sensitive sensory neurons
Carlo Alberto Maggi,Alberto Meli +1 more
TL;DR: Development of drugs capable of controlling the sensory-efferent functions of the capsaicin-sensitive sensory neurons represent a new and very promising area of research for pharmacological treatment of various human diseases.
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Tachykinin receptors and tachykinin receptor antagonists
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Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves
TL;DR: Neuroeffector roles of tachykinins and CGRP released from primary afferent neurons 6.2.1 Pathoph:ysiological implications 6.3.1.
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Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation.
Alois Saria,Claes-Roland Martling,Zhao Yan,Elvar Theodorsson-Norheim,Rainer Gamse,Jan M. Lundberg +5 more
TL;DR: High performance liquid chromatography indicated that NKA-LI consisted of several cross-reacting substances, presumably other peptides of the tachykinin family, which was the most potent one to contract tracheal smooth muscle of guinea pigs in vitro.
References
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Journal ArticleDOI
Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor.
TL;DR: The primary structures of two types of bovine brain substance P precursors have been determined and one precursor contains a sequence homologous to that of the amphibian peptide kassinin, which suggests that it can be liberated from the precursor and may serve as an endogenous hormone or neuromediator in mammalian organisms.
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Capsaicin-induced depletion of substance P from primary sensory neurones.
TL;DR: Observations strongly support the concept that substance P acts as a primary sensory transmitter and the administration of capsaicin, which is known to desensitize peripheral receptors responding to painful chemogenic stimuli, virtually abolishes the fluoride-resistant acid phosphatase activity of the substantia gelatinosa.
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Decrease of substance p in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin
TL;DR: The results indicate that the action of capsaicin on substance P neurones is restricted to primary sensory neurones and it is suggested that release of substance P is involved in neurogenic plasma extravasation.
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Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing.
TL;DR: Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.
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Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
TL;DR: The functional evidence for the importance of SP in the vagal and non-vagal (spinal) control of bronchial smooth muscle tone and vascular permeability is supported by the present experimental findings of SP-IR nerves in the lower respiratory tract.