Showing papers in "Neuroscience in 1988"

TL;DR: Etude du mecanisme d'action des neurones sensoriels et des fonctions de leurs effecteurs locaux en reponse a differents stimuli, au niveau des tissus directement en contact avec l'environnement exterieur.

TL;DR: In hippocampal neurons, a Ca-activated K channel which may be responsible for the slow AHP has been identified in single channel recordings, however, this channel has unique properties and it is not blocked by Apamin, suggesting that more than one subclass of Ca- activated K channel may mediate slow AHPs.

TL;DR: Consideration of morphological and connectional characteristics of basal forebrain suggests that the corticopetal cell groups, together with magnocellular elements of the striatum, serve similar functional roles for the striatopallidal system, the extended amygdala, and the septal-diagonal band complex.

TL;DR: The results of the present experiments indicate that the mediodorsal nucleus, on the basis of its cyto-, myelo- and chemoarchitecture as well as the organization of its reciprocal connections with the prefrontal cortex, can be subdivided into a medial, a central, a lateral and a paralamellar segment.

TL;DR: In conditions which mimicked the spontaneous activity of dopaminergic neurons when they switch from one pattern to the other, the bursting stimulations were found to be up to 6 times more potent than regularly spaced stimulation, suggesting bursting might be much more important than mean firing frequency as regards the functional efficacy of DA neurons.

TL;DR: The ontogeny of the dopaminergic system was studied in detail with immunocytochemical methods employing antibodies against dopamine to test the hypothesis that dopamine plays an organizational role in the development of the striatum.

TL;DR: It is reported that N-methyl-D-aspartate indeed has a dramatic effect on the survival in culture of cells derived from dissociated cerebella of 7-8-day-old rats and cultured in media containing 'low' [K+]e (5-15 mM).

TL;DR: The experimentalData was found to be successfully modelled when the balance of uptake and stimulated overflow was considered, and the fit of the modelled data to the experimental data was improved when diffusion from the release and uptake sites was considered.

TL;DR: The data show that the peptide-containing locus coeruleus neurons have efferent projections to the spinal cord, hypothalamus and cerebral cortex.

TL;DR: The distribution of stained terminals remaining in cortical areas with lesioned basal forebrain innervation suggests that the basal fore brain projection to cerebral cortex, and not the intrinsic cortical cholinergic neurons, give rise to the laminar distribution of cholinergy terminals observed in normal cortex.

TL;DR: Both monoamine oxidase A and B were localized in distinct populations of neurons in the lateral and tuberal regions of the hypothalamus, a region shown recently to contain histamine neurons in rats.

TL;DR: The results suggest that microdialysis is a useful way to study norepinephrine release in hippocampus and they permit several conclusions to be drawn, including that nerve terminal density is an important factor in determining the concentration of catecholamines in the extracellular fluid.

TL;DR: Both alpha-C GRP and beta-CGRP occur in the rat nervous system and are both biologically active.

TL;DR: The striking retrograde cell labeling observed after injections in nuclei with associative functions and widespread cortical projections was due to massive afferentation from non-cholinergic parts of the midbrain and pontine reticular formation, on both ipsi- and contralateral sides.

TL;DR: Novel findings of this study include the degeneration of some dentate basket cells and lateral septal neurons and the appearance of terminal-like argyrophilia in the hippocampal formation without any obvious relation to somatic degeneration.

TL;DR: Results provide direct evidence that calcitonin gene-related peptide is a marker for a major subset of visceral primary afferent neurons and suggest that this population of spinal afferents makes a major contribution to the total gastric content of calcitonIn gene- related peptide.

TL;DR: The retrograde transport of wheat germ agglutinin conjugated with horseradish peroxidase with choline acetyltransferase immunohistochemistry was used to study the projections of cholinergic and non-cholinergic neurons of the upper brainstem core to rostral and caudal intralaminar thalamic nuclei, reticularThalamic complex and zona incerta in the cat.

TL;DR: Results indicate that MK-801 can protect hippocampal neurons from ischaemia-induced neuronal degeneration when it is administered up to 24 h after the insult, and provide further evidence that therapeutic intervention in the post-ischaemic period can successfully prevent neurodegenerative events.

TL;DR: The present results provide direct evidence that zinc might be a relatively potent, rapidly acting neurotoxin, and somewhat less potent gliotoxin, in the mammalian central nervous system and should be included on the growing list of endogenous toxins which may be involved in the acute pathogenesis of central neuronal, and possibly glial, cell loss in some disease states.

TL;DR: Commentaires a propos des criteres neuropsychologiques de la demence «subcorticale», des similarites ou differences avec les demences de type cortical en se fondant sur les troubles du comportement, langage, memoire et fonctions visuospatiales.

TL;DR: Ablation of capsaicin-sensitive afferent neurons enhances experimentally induced ulceration in the rat gastric mucosa, which suggests that these neurons are involved in Gastric mucosal protection as mentioned in this paper.

TL;DR: It is concluded that the Ca2+-independent release of cytoplasmic glutamate may make the major contribution to the excitotoxic release of glutamate in hypoglycaemic and anoxic conditions.

TL;DR: Preliminary results indicate that the binding of both [ 3H]imipramine and [3H]paroxetine is diminished in the brain of patients treated with imipramines, and seems to indicate thatThe ascending serotonergic pathways are the main site of action of antidepressants.

TL;DR: The results indicate that the effectiveness of equimolar doses of angiotensin II-(3-8)-hexapeptide and angiotENSin II in improving processes related to learning and memory in rats is almost identical and thus must be independent of specific ang Elliotensin receptors in brain to which the hexapeptides binds with about 1000 times lower affinity than angiotsin II.

TL;DR: The results indicate that striatal grafts can provide a substantial amelioration of motor impairments induced by striatal lesions, and suggest that the graft's influence on the host brain is itself under the functional regulation of an afferent dopaminergic input from the hostbrain.

TL;DR: Brainstem afferents to various nuclei of the basal forebrain of the rat were examined using the retrograde transport of wheat germ agglutinin-horseradish peroxidase to identify the major brainstem projections to each of the forebrain sites.

TL;DR: Advantages and problems encountered in the use of each technique in assessing neurotoxic effects are revealed, forming a basis for discussion of the relative merits of using a battery of specific molecular probes for neurotoxicity evaluations.

TL;DR: The present data suggest that MPTP preferentially destroys dopamine cells that project to the striatum, which is most extensive in the two monkeys which exhibited the most severe parkinsonian syndrome.

TL;DR: Evidence is provided for the presence and non-uniform distribution of multiple peptide neurotransmitters in vagal and glossopharyngeal afferent ganglia of the rat and for multiple neuropeptides involved as afferent neurotransmitter in the reflexes mediated by vagAL and glossophileal sensory nerves.

TL;DR: Single channels activated by externally applied ATP were investigated in cultured sensory neurons from nodosal and spinal ganglia of rat using patch clamp and concentration clamp methods, indicating that ATP as a free anion can activate the receptor.