Journal ArticleDOI
Myelodysplasia progressing to acute myeloblastic leukemia in an HTLV-III virus-positive homosexual man with AIDS-related complex.
Reads0
Chats0
TLDR
The association of HTLV-III infection with myelodysplasia and acute myeloblastic leukemia may have been coincidental in this reported case, but it is also possible that the leukemia was secondary to the HTLV -III infection.Abstract:
Myelodysplastic changes have recently been described in patients with the acquired immunodeficiency syndrome (AIDS). The authors report a patient with AIDS-related complex and myelodysplasia who rapidly progressed to acute myeloblastic leukemia. Infection with human T-cell lymphotropic virus type III (HTLV-III) was documented by culture and by serology. Chromosome studies showed monosomy of chromosome 7 and structural abnormality of the long arm of chromosome 3. The association of HTLV-III infection with myelodysplasia and acute myeloblastic leukemia may have been coincidental in this reported case, but it is also possible that the leukemia was secondary to the HTLV-III infection. Further investigation appears justified.read more
Citations
More filters
Journal ArticleDOI
Three new cases of chromosome 3 rearrangement in bands q21 and q26 with abnormal thrombopoiesis bring further evidence to the existence of a 3q21q26 syndrome.
TL;DR: Further evidence is brought to the existence of a cytogenetic syndrome involving bands q21 and q26 simultaneously, which represents a subtype of ANLL, MDS, and MPD, characterized by normal or elevated platelet counts, hyperplasia with dysplasia of megakaryocytes, multilineage involvement, young median age of patients with MDS.
Journal ArticleDOI
Hematologic abnormalities in AIDS.
TL;DR: Novel clinical approaches using hematopoietins alone or in combination with antimicrobial, antiviral, and antitumor drugs represent exciting developments in the treatment of HIV infection.
Journal ArticleDOI
Hematologic aspects of human immunodeficiency virus infection: laboratory and clinical considerations.
TL;DR: This review will focus on HIV‐associated cytopenias and coagulation abnormalities and their occurrence, laboratory evaluation, and clinical significance and the mechanisms underlying their development.
Journal ArticleDOI
Immunologic abnormalities in myelodysplastic syndromes.
TL;DR: In myelodysplastic syndromes, several autoimmune phenomena are more common than expected and molecular studies suggest that the lymphoid system may be involved in the dysplastic process.
Journal ArticleDOI
Histopathology of bone marrow in human immunodeficiency virus infection.
TL;DR: The clinical and haematological findings in 18 patients with human immunodeficiency virus (HIV) infection were correlated with the histological features of plastic embedded bone marrow biopsies, highly suggestive of HIV infection.
References
More filters
Journal ArticleDOI
The Acquired Immunodeficiency Syndrome: An Update
TL;DR: The acquired immunodeficiency syndrome continues to be a major public health problem in the United States, and recently its spread worldwide has accelerated.
Journal ArticleDOI
Hematologic abnormalities in the acquired immune deficiency syndrome
TL;DR: The high incidence of myelofibrosis, alterations in marrow cellularity, pancytopenia, and hematophagic histiocytosis indicates that the bone marrow is a target organ in AIDS.
Journal ArticleDOI
Generalized lymphadenopathy in homosexual men.
Craig E. Metroka,Susanna Cunningham-Rundles,Marilyn S. Pollack,Joseph A. Sonnabend,John M. Davis,Bruce Gordon,Richard D. Fernandez,Janet Mouradian +7 more
TL;DR: It is suggested that generalized lymphadenopathy is part of the spectrum of a disorder manifested by acquired immunodeficiency, opportunistic infections, Kaposi's sarcoma, and malignant lymphomas.
Journal ArticleDOI
Genetically determined immunodeficiency diseases (GDID) and malignancy: report from the immunodeficiency--cancer registry.
TL;DR: Possible biases in the case registry are discussed, including the possibility that certain immunodeficiencies are underrepresented, that certain tumors are overreported, and that diagnostic criteria of lymphomas have changed in the years that ICR cases were diagnosed.
Journal ArticleDOI
Cytogenetic Studies in 174 Consecutive Patients With Preleukemic or Myelodysplastic Syndromes
TL;DR: Routine cytogenetic studies were done in 174 consecutive patients with preleukemic or myelodysplastic syndromes (PL/MDS), and each patient with the 5q - syndrome had a 5q-chromosome, as this is a prerequisite for the diagnosis.