Journal ArticleDOI
Neurobehavioral teratology of isotretinoin
Jane Adams,Edward J. Lammer +1 more
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This article is published in Reproductive Toxicology.The article was published on 1993-03-01. It has received 48 citations till now.read more
Citations
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Journal ArticleDOI
Children's health and the environment: public health issues and challenges for risk assessment.
TL;DR: The adequate protection of children against toxic agents in the environment will require fundamental and far-reaching revisions of current approaches to toxicity testing and risk assessment.
Journal ArticleDOI
Neural Development, Cell-Cell Signaling, and the “Two-Hit” Hypothesis of Schizophrenia
TL;DR: In this paper, the authors proposed a two-hit hypothesis for the development of schizophrenia, where genetic or environmental factors disrupt early central nervous system (CNS) development and then lead to the onset of schizophrenia symptoms.
Journal ArticleDOI
Teratology of retinoids.
Michael D. Collins,Gloria E. Mao +1 more
TL;DR: An overview of the principles of teratology as they apply to retinoid-induced malformations are given and relevant aspects of the biochemical pathway and signal transduction of retinoids are described.
Book
Principles for evaluating health risks in children associated with exposure to chemicals
TL;DR: First drafts prepared by Dr Germaine Buck Louis, Bethesda, USA; Dr Terri Damstra, Research Triangle Park, USA and Dr Ulrike Luderer, Irvine, USA.
Journal ArticleDOI
Periconceptional vitamin a use: How much is teratogenic?
TL;DR: Blood levels of retinoids from women taking 30,000 IU/d of preformed vitamin A are not greater than retinoid blood levels in pregnant women during the first trimester who delivered healthy babies, indicating that women living in industrialized countries or who otherwise have nutritionally adequate diets may not need to ingest more than the Recommended Dietary Allowance of pre formed vitamin A as supplements.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Book ChapterDOI
Principles of Behavioral Teratology
TL;DR: In this paper, the principles of behavioral teratogenic response were defined as an extension of Wilson's concepts, which were most recently presented in 1977 (Wilson, 1977) and defined as a set of principles and mechanisms of teratogenesis.
Journal ArticleDOI
The relationship of gestational age to vitamin A induced postnatal dysfunction
TL;DR: In an effort to determine the relationship between time of administration and consequent behavioral effects on progeny, a uniform subteratogenic dose of vitamin A was administered to gravid Sprague-Dawley rats during one of five periods of gestation.