Journal ArticleDOI
Nonadrenergic inhibitory nervous system in human airways.
J. Richardson,J. Beland +1 more
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TLDR
It is suggested that a defect in the airway system, such as that shown in the gastrointestinal tract, may be an explanation for the hyperreactive airways of asthma and chronic bronchitis.Abstract:
Human airways, from the middle of the trachea to the distal bronchi, were studied in vitro for the presence of inhibitory nerves. The tissue was obtained from operations and from recent autopsies. ...read more
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Journal ArticleDOI
Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
TL;DR: The functional evidence for the importance of SP in the vagal and non-vagal (spinal) control of bronchial smooth muscle tone and vascular permeability is supported by the present experimental findings of SP-IR nerves in the lower respiratory tract.
Journal ArticleDOI
Pharmacology and Therapeutics of Bronchodilators
TL;DR: An important step in simplifying asthma and COPD management and improving adherence with prescribed therapy is to reduce the dose frequency to the minimum necessary to maintain disease control, so the incorporation of once-daily dose administration is an important strategy to improve adherence.
Journal ArticleDOI
Localization of VIP-immunoreactive nerves in airways and pulmonary vessels of dogs, cats, and human subjects
TL;DR: Findings provide an anatomic basis for the possible modulation of airway and pulmonary vascular function by this neuropeptide.
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Obesity and asthma
TL;DR: Obesity appears to be a particularly important issue for severe asthma, and there are also plausible biological mechanisms whereby obesity could be expected to either cause or worsen asthma.
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