Novel Coronavirus Disease (COVID-19) in Italian Patients: Gender Differences in Presentation and Severity
Martina Baiardo Redaelli,Giovanni Landoni,Davide Di Napoli,Federica Morselli,Marianna Sartorelli,Chiara Sartini,Annalisa Ruggeri,Andrea Salonia,Lorenzo Dagna,Alberto Zangrillo +9 more
TLDR
In this paper, the gender-related differences in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital, Milan, Italy were assessed.Citations
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ECMO in COVID-19 Patients: A Systematic Review and Meta-analysis
TL;DR: In this paper , the authors performed a systematic review and meta-analysis to assess the impact of ECMO as supportive therapy of COVID-19, and the reported mortality rate was 39%.
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One-Year Multidisciplinary Follow-Up of Patients With COVID-19 Requiring Invasive Mechanical Ventilation
TL;DR: In this article , the authors investigated 1-year survival, quality of life, and functional recovery of patients with COVID-19-related acute respiratory distress syndrome requiring invasive mechanical ventilation.
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A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19
Emanuele Nicastri,Franco Marinangeli,Emanuele Pivetta,Elena Torri,Francesco Reggiani,Giuseppe Fiorentino,Laura Scorzolini,Serena Vettori,Carolina Marsiglia,Elizabeth Marie Gavioli,Andrea R. Beccari,Giuseppe Terpolilli,Maria De Pizzol,G Goisis,Flavio Mantelli,Francesco Vaia,Marcello Allegretti +16 more
TL;DR: Raloxifene was found as a promising molecule to treat COVID-19 due to its activity to modulate the replication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and act as an immunomodulator to decrease proinflammatory cytokines as discussed by the authors .
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High Risk Coronavirus Disease 2019: The Primary Results of the CoronaHeart Multi-Center Cohort Study.
Patrícia O. Guimarães,Patrícia O. Guimarães,Francis R. de Souza,Renato D. Lopes,Cristina Salvadori Bittar,Francisco Akira Malta Cardozo,Bruno Caramelli,Daniela Calderaro,Cicero Piva de Albuquerque,Luciano F. Drager,Fausto Feres,Luciano Moreira Baracioli,Gilson Soares Feitosa Filho,Roberto Ramos Barbosa,Henrique Barbosa Ribeiro,Expedito E. Ribeiro,Renato J. Alves,Alexandre de Matos Soeiro,Bruno L. R. Faillace,Estêvão Lanna Figueiredo,Lucas P. Damiani,Renata do Val,Natassja Huemer,Lisiê G. Nicolai,Ludhmila Abrahão Hajjar,Alexandre Abizaid,Roberto Kalil Filho +26 more
TL;DR: In this paper, the authors found that patients with COVID-19 and high risk features have an elevated rate of in-hospital mortality with differences according to age and sex, while older men presented higher rates of death than women (57.6% vs 49.2%).
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Same but Different—ECMO in COVID-19 and ARDS of Other Etiologies. Comparison of Survival Outcomes and Management in Different ARDS Groups
TL;DR: In this paper , the authors analyzed venovenous extracorporeal membrane oxygenation (ECMO) management and survival outcomes in patients with COVID-19 in comparison to influenza ARDS and pulmonary ARDS of other origin.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
The trinity of COVID-19: immunity, inflammation and intervention.
Matthew Zirui Tay,Chek Meng Poh,Laurent Rénia,Laurent Rénia,Paul A. MacAry,Lisa F. P. Ng,Lisa F. P. Ng,Lisa F. P. Ng +7 more
TL;DR: The interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression is described and the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation are highlighted.
Journal ArticleDOI
Sex differences in immune responses
Sabra L. Klein,Katie L. Flanagan +1 more
TL;DR: It is emphasized that sex is a biological variable that should be considered in immunological studies and contribute to variations in the incidence of autoimmune diseases and malignancies, susceptibility to infectious diseases and responses to vaccines in males and females.
Journal ArticleDOI
Gender Differences in Patients With COVID-19: Focus on Severity and Mortality
TL;DR: While men and women have the same prevalence, men with COVID-19 are more at risk for worse outcomes and death, independent of age.
Journal ArticleDOI
The complex role of estrogens in inflammation
TL;DR: This review reinforces the concept that estrogens have antiinflammatory but also proinflammatory roles depending on above-mentioned criteria and explains that a uniform concept as to the action of estrogens cannot be found for all inflammatory diseases due to the enormous variable responses of immune and repair systems.
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