Journal ArticleDOI
On the central sites for the antinociceptive action of morphine and fentanyl
TLDR
The inhibition by morphine and fentanyl of a nociceptive response, the licking reaction elicited by electrical stimulation of the tooth-pulp, was studied in rabbits and the most effective sites of the antinociception action of morphine-like substances were situated in the fossa rhomboides and structures near it.About:
This article is published in Neuropharmacology.The article was published on 1970-11-01. It has received 266 citations till now. The article focuses on the topics: Morphine.read more
Citations
More filters
Journal ArticleDOI
Analgesia mediated by a direct spinal action of narcotics.
Tony L. Yaksh,T. A. Rudy +1 more
TL;DR: Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone.
Journal ArticleDOI
Analgesia from Electrical Stimulation in the Brainstem of the Rat
TL;DR: Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving responsiveness to other sensory modes relatively unaffected.
Journal ArticleDOI
Central nervous system mechanisms of analgesia.
David J. Mayer,Donald D. Price +1 more
TL;DR: The intent of this review is to examine and synthesize the extensive progress that has been made in the last few years describing the anatomical, physiological and neurohumoral substrates of neural systems which modulate pain perception.
Journal ArticleDOI
Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis
TL;DR: It is proposed that focal electrical stimulation activates a pain suppressive system concentrated in periventricular and periaqueductal regions and its activation reduces responsiveness to noxious stimuli, at least in part, by blocking transmission of nociceptive information through the spinal cord.
Journal ArticleDOI
Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques
Tony L. Yaksh,Thomas A. Rudy +1 more
TL;DR: Experimental approaches are resorted to which permit a detailed study of the interaction between narcotic analgetics and particular regions and/or functional systems within the central nervous system.
References
More filters
Journal ArticleDOI
A method for the combined staining of cells and fibers in the nervous system.
Journal ArticleDOI
Effects of thalamic stimulation in unanaesthetised animals; the arrest reaction and petit mal-like seizures, activation patterns and generalized convulsions.
TL;DR: It is concluded from observations in the cat that the diffuse thalamo-cortical projection system which is called the thalamic reticular system has a very widespread and profound effect on behaviour as a whole and may be involved in the mechanism of petit mal and generalized convulsive seizures as seen in man.
Journal ArticleDOI
Stimulation of periaqueductal gray and hypothalamus.
TL;DR: Numerous reports are to be found in the literature pertaining to a group of somatomotor and autonomic responses in experimental animals which are described by a host of names, the more common of which are rage, fear, or flight.