Journal ArticleDOI
Opiate Receptor: Demonstration in Nervous Tissue
TLDR
Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine that closely parallels their pharmacological potency.Abstract:
Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.read more
Citations
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Endogenous opioid peptides: multiple agonists and receptors
TL;DR: It is concluded that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.
Journal ArticleDOI
Purification and properties
TL;DR: It is an opioid agonist on the guinea pig myenteric plexus-longitudinal muscle preparation, and on the mouse vas deferens, and it binds to opiate receptors in homogenates of Guinea pig brain.
Journal ArticleDOI
Prolactin: Structure, Function, and Regulation of Secretion
TL;DR: The purpose of this review is to provide a comprehensive survey of the current understanding of prolactin's function and its regulation and to expose some of the controversies still existing.
Journal ArticleDOI
Pain and its effects in the human neonate and fetus
TL;DR: The body of scientific evidence regarding the mechanisms and effects of nociceptive activity in newborn infants has not been addressed directly and the pervasive view of neonatal pain is that newborns are frequently not given analgesic or anesthetic agents during invasive procedures, including surgery.
Journal ArticleDOI
Benzodiazepine receptors in rat brain
Squires Rf,Brastrup C +1 more
TL;DR: Experiments suggest that another important group of psychoactive drugs, the benzodiazepines, bind to specific receptors on the membranes of rat brain cells, and this suggests that there may be an unknown endogenous neurotransmitter which is the natural ligand for the Benzodiazepine receptor.
References
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Journal Article
Dopamine (3-hydroxytyramine) and brain function
TL;DR: A good case can be made for the concept that the physiological activity of the brain dopamine is quite different from that of brain norepinephrine, although there are as yet no experiments to positively show that dopamine is a true neuro-transmitter substance in the brain.
Journal ArticleDOI
The origin of acetylcholine released from guinea‐pig intestine and longitudinal muscle strips
William D.M. Paton,M. Aboo Zar +1 more
TL;DR: Strips of longitudinal muscle can be obtained from guinea‐pig ileum either retaining or free from Auerbach's plexus, as well as from other guinea-pig models, using a single Caesarean section as an example.
Journal ArticleDOI
Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain
TL;DR: In mouse brain the stereospecific binding of levorphanol represents only 2% of the total association of drug with tissue, and it was found only in certain membrane fractions.
Journal ArticleDOI
The effect of analgesic drugs on the release of acetylcholine from electrically stimulated guinea‐pig ileum
Brian M. Cox,Marta Weinstock +1 more
Journal ArticleDOI
The use of microwave radiation in the determination of acetylcholine in the rat brain
TL;DR: It was concluded that sacrificing rats by microwave irradiation, coupled with pyrolysis-gas chromatographic analysis of ACh, permitted a more accurate and convenient determination of in vivo levels of A Ch in brain areas.