Journal ArticleDOI
ORTHO METALATION DIRECTED BY α-AMINO ALKOXIDES
Daniel L. Comins,Jack D. Brown +1 more
TLDR
In this article, the dialkyl amidures de lithium sur des aldehydes aromatiques (naphtalenecarbaldehydes, benzene substitues) dans le THF ou le benzene, conduit a des hemiaminals qui sont lithies en position ortho par le butyl-lithium L'alkylation suivie de l'hydrolyse, des produits lithies fournit les arenals substitues en orthoAbstract:
L'addition de dialkyl amidures de lithium sur des aldehydes aromatiques (naphtalenecarbaldehydes, benzaldehydes substitues) dans le THF ou le benzene, conduit a des hemiaminals qui sont lithies en position ortho par le butyl-lithium L'alkylation suivie de l'hydrolyse, des produits lithies fournit les arenals substitues en orthoread more
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Journal ArticleDOI
Thienoacene‐Based Organic Semiconductors
TL;DR: This Review focuses on four classes of thienoacenes, which are classified in terms of their chemical structures, and elucidates the molecular electronic structure of each class, and provides insight into new molecular design strategies for the development of superior organic semiconductors.
Journal ArticleDOI
Practical Route to a New Class of LTD4 Receptor Antagonists
Robert D. Larsen,Edward G. Corley,Anthony O. King,James D. Carroll,Paul Davis,Thomas R. Verhoeven,Paul J. Reider,Marc Labelle,Jacques Yves Gauthier,Xiang Yi Bin,Robert Zamboni +10 more
TL;DR: In this paper, a general approach to the synthesis of a new class of LTD4 antagonists is presented, based on the diarylpropane framework, which is prepared by Claisen−Schmidt condensation and selective reduction of the enone.
Book ChapterDOI
Directed Metalation of Pi-Deficient Azaaromatics: Strategies of Functionalization of Pyridines, Quinolines, and Diazines
TL;DR: In this article, the directed ortho metalation (DoM) reaction of pyridines, quinolines, pyrimidines and pyrazines has been extensively studied.
Journal ArticleDOI
Toluene Dioxygenase-Mediated cis-Dihydroxylation of Aromatics in Enantioselective Synthesis. Asymmetric Total Syntheses of Pancratistatin and 7-Deoxypancratistatin, Promising Antitumor Agents1
TL;DR: In this article, the coupling of a higher order cyanocuprate (derived by ortho-metalation from N,N-dimethyl-2-[(tert-butyldimethylsilyl)oxy]-3,4-(methylenedioxy)benzamide) with aziridine 7 to generate 28 contains the carbon framework of the title alkaloid.
Journal ArticleDOI
Generation of Secondary, Tertiary, and Quaternary Centers by Geminal Disubstitution of Carbonyl Oxygens
TL;DR: Methods for replacing the carbonyl oxygen by two new substituents (C=O→CR(1)R(2)) are discussed in this Minireview, whereby R may be H, NR(2), alkyl, allyl, benzyl, vinyl, alkynyl, aryl, heteroaryl, or acyl groups.