Journal ArticleDOI
Outflow resistance of enucleated human eyes at two different perfusion pressures and different extents of trabeculotomy.
TLDR
The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.Abstract:
Aqueous outflow resistance of enucleated human eyes was measured at 7 and 25 mm Hg before and after partial and complete (12 clock hours) internal trabeculotomy. Following complete trabeculotomy, 71% of the resistance was eliminated at 25 mm Hg while only 49% was eliminated at 7 mm Hg. In contrast to published findings in eyes with intact trabecular meshwork where the resistance increased with increasing IOP (1), following complete trabeculotomy, the resistance decreased 2% per mm Hg with increasing IOP. Experiments with trabeculotomy limited to part of the circumference showed that a one hour trabeculotomy produced 41% (25 mm Hg) to 60% (7 mm Hg) of the effect of a twelve hour trabeculotomy. The results indicate that a surprisingly high fraction of aqueous outflow resistance resides in the distal aspects of the outflow system at normal IOP, and that this distal resistance drops as IOP is increased.read more
Citations
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Journal ArticleDOI
Micro-invasive glaucoma surgery: current perspectives and future directions.
Hady Saheb,Iqbal Ike K. Ahmed +1 more
TL;DR: MIGS procedures offer reduction in IOP, decrease in dependence on glaucoma medications and an excellent safety profile, which differs from the role of more invasive glAUcoma surgeries such as trabeculectomy or glau coma drainage devices.
Journal ArticleDOI
Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract.
TL;DR: Pressure reduction on fewer medications was clinically and statistically significantly better 1 year after stent plus cataract surgery versus cataracts surgery alone, with an overall safety profile similar to that of catarACT surgery alone.
Journal ArticleDOI
Extracellular matrix in the trabecular meshwork.
Ted S. Acott,Mary J. Kelley +1 more
TL;DR: Changes in ECM associated with open-angle glaucoma have been identified and several cytokines, growth factors and drugs, which affect the outflow resistance, change ECM component expression, mRNA alternative splicing, cellular cytoskeletal organization or all of these.
Journal ArticleDOI
What controls aqueous humour outflow resistance
TL;DR: Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.
Journal ArticleDOI
Pressures in the juxtacanalicular tissue and Schlemm's canal in monkeys.
Olav Mäepea,Anders Bill +1 more
TL;DR: A micropuncture technique involving the use of microcannulas with tip diameters less than 5 microns was used to measure the pressure in Schlemm's canal and in the meshwork, indicating that at the spontaneous IOP about 75% of the resistance between the anterior chamber and Schle mm's canal is located within 14 microns from the canal.
References
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Journal ArticleDOI
Experimental aqueous perfusion in enucleated human eyes.
TL;DR: In study of the mechanics of the outflow channels, good use has been made of aqueous perfusion of the eye when in vivo or in study of elastic properties of the eyes.
Journal ArticleDOI
Further studies on facility of flow through the trabecular meshwork.
TL;DR: In 1954 and 1955 preliminary results were reported on attempts at measuring directly how much of the normal resistance to outflow of aqueous humor is attributable to the trabecular meshwork in human eyes.
Journal Article
The role of Schlemm's canal in aqueous outflow from the human eye.
Mark Johnson,Roger D. Kamm +1 more
TL;DR: A mathematical model is developed to simulate collapse of the canal and its effect on resistance to flow through the aqueous outflow network and tentative conclusions are reached that glaucoma is not caused by a weakening of the trabecular meshwork and a resultant collapse of Schlemm's canal alone.
Journal ArticleDOI
Anatomical Study of Schlemm's Canal and Aqueous Veins by Means of Neoprene Casts Part I. Aqueous Veins
Journal ArticleDOI
Argon laser trabeculoplasty. Studies of mechanism of action.
TL;DR: The effects of argon laser trabeculoplasty (LTP) on outflow facility, Schlemm's canal morphology, trabellular cellularity, and trabcellular glycosaminoglycan composition were determined in 33 pairs of eye-bank human eyes as discussed by the authors.
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