Journal ArticleDOI
Partition data of penicillins determined by means of reversed-phase thin-layer chromatography.
TLDR
RM values were calculated by interpolation or extrapolation from the ranges of linearity between RM values and composition of the mobile phase and the influence of substituent groups on the RM values of the penicillins.About:
This article is published in Journal of Chromatography A.The article was published on 1969-01-01. It has received 194 citations till now.read more
Citations
More filters
Journal ArticleDOI
Determination of hydrophobic parameters by reversed-phase liquid chromatography: theory, experimental techniques, and application in studies on quantitative structure-activity relationships
TL;DR: It is suggested that retention parameters, in particular the capacity factor obtained by extrapolation of retention data from binary eluents to 100% water, could successfully replace the n-octanol-water partition coefficient in studies on quantitative structure-activity relationship, and that their use may result in a better correlation with biological data.
Journal ArticleDOI
Chromatographic hydrophobic parameters in correlation analysis of structure-activity relationships.
TL;DR: It is suggested that the chromatographically obtained RM and delta RM parameters could find a wider applicability in structure-activity relationships, and that their use would result in improved correlation of data.
Journal ArticleDOI
Quantitative structure-activity relationships for herbicides: reversed-phase liquid chromatographic retention parameter, log kw, versus liquid-liquid partition coefficient as a model of the hydrophobicity of phenylureas, s-triazines and phenoxycarbonic acid derivatives
TL;DR: In this paper, the retention behavior of phenylureas, s-triazines and phenoxycarbonic acid derivatives in a reversed-phase high-performance liquid chromatographic (RPLC) system has been examined.
Journal ArticleDOI
Simple procedure for determining octanol-aqueous partition, distribution, and ionization coefficients by reversed-phase high-pressure liquid chromatography
TL;DR: The described simple, accurate, and precise reversed-phase high-pressure liquid chromatographic procedure is in excellent agreement with 1-octanol shake-flask partition or distribution coefficients over a 3.5 log range.
Journal ArticleDOI
The Clinical Pharmacokinetics of Rifabutin
TL;DR: The clinical effectiveness of rifabutin for prophylaxis of disseminated Mycobacterium avium complex infection has recently been demonstrated in HIV-positive patients with low CD4 counts, and more clinical studies are needed to establish the role of r ifabut in combination therapy for M. avium-intracellulare complex and other mycobacterial infections.
References
More filters
Journal ArticleDOI
p-σ-π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
Corwin Hansch,Toshio Fujita +1 more
Journal ArticleDOI
A New Substituent Constant, π, Derived from Partition Coefficients
Journal ArticleDOI
Qualitative analysis of proteins: a partition chromatographic method using paper.
Journal ArticleDOI
Chromatographic behaviour and chemical structure I. Some naturally occuring phenolic substances
E.C. Bate-Smith,R.G. Westall +1 more
TL;DR: In this article, it was shown that the RF values are related to the nature and number of substituent groups in the C15 and C6 skeleton, respectively, in such a way that in many instances a straight line is given when log I R F − I is plotted against the number of subsets of any one kind.
Related Papers (5)
A Simple Assessment of Partition Data for Correlating Structure and Biological Activity Using Thin-Layer Chromatography
C. B. C. Boyce,B. V. Milborrow +1 more