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Open AccessJournal ArticleDOI

Pathogenesis of visual field defects. Role of the ciliary circulation.

Sohan Singh Hayreh
- 01 May 1970 - 
- Vol. 54, Iss: 5, pp 289-311
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TLDR
The present study demonstrates such a sectoral blood supply in the optic nerve head and choroid and is of considerable significance in explaining the site of the lesion and the pathogenesis of these defects.
Abstract
Clinically the presence of nerve fibre bundle defects in glaucoma and non-glaucomatous lesions, and altitudinal or vertical hemianopias in pre-chiasmal lesions has been known for a long time. These suggest a sectoral lesion in the optic nerve or retina. In the majority of such cases, no retinal lesion is seen to account for these visual field defects. It has been presumed that the lesion lies in the optic nerve. Such a visual field defect can be produced only by a sectoral lesion. Most of these field defects are considered to be vascular in origin, but studies of the blood supply of the optic nerve have so far failed to demonstrate any segmental blood supply to the nerve which could explain them. The present study demonstrates such a sectoral blood supply in the optic nerve head and choroid and is of considerable significance in explaining the site of the lesion and the pathogenesis of these defects.

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Citations
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Journal ArticleDOI

Ischemic optic neuropathy.

TL;DR: Emerging information on the various factors that influence the optic nerve circulation, and also the various systemic and local risk factors which play important roles in the development of various types of ischemic optic neuropathy have given a better understanding of their pathogeneses, clinical features and management.
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Mechanisms of optic nerve damage in primary open angle glaucoma

TL;DR: An enhanced understanding of the nature of the optic nerve damage in POAG and improved methods of study may result in earlier diagnosis or allow us to distinguish among different pathological processes all currently grouped under the diagnosis of POAG.
Journal Article

Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey.

TL;DR: Serial reconstructions of radioautographs and peroxidase-reacted sections of the optic nerve heads demonstrated that the orthograde and retrograde transport obstructions were coincidental anatomically by light microscopy in the LS and occurred most prominently in the temporal quadrants of the nerve head.
Journal ArticleDOI

The blood supply of the optic nerve head and the evaluation of it - myth and reality.

TL;DR: The objective of this paper is to differentiate myths and misconceptions from reality about the OnH blood supply; to elucidate the reasons for disagreement on the blood supply of the ONH; and to evaluate the reliability and validity of various methods currently used to measure ONH blood flow.
Journal ArticleDOI

Central retinal artery occlusion: visual outcome.

TL;DR: In this article, the authors investigate systematically the natural history of visual outcome in central retinal artery occlusion (CRAO), and classify CRAO eyes into four categories: non-arteritic (NA) CRAO, arteritic (AR), NA-CARO with cilioretinal artery sparing (35), transient NA-CRO (41), and arteritic CRAO (13).
References
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Journal ArticleDOI

Common Pathological Basis of the Nervous Ocular Symptoms in Chronic Glaucoma: A Preliminary Note *

TL;DR: The nature of the vascular alteration of the nerve fibre in glaucomatous atrophy is investigated to investigate the pathogenesis of hypertension and the field changes associated with a pathological tissue change.
Journal ArticleDOI

Relation of field contraction to blood pressure in chronic primary glaucoma

TL;DR: It is common experience that in cases of chronic primary glaucoma there is often an inconsistency between the height of the intraocular pressure and the rate of contraction of the visual fields.