Phosphorylation coupled to oxidation of dihydrodiphosphopyridine nucleotide.
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This article is published in Journal of Biological Chemistry.The article was published on 1951-05-01 and is currently open access. It has received 381 citations till now. The article focuses on the topics: Phosphorylation & Nucleotide.read more
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Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
TL;DR: The results are shown to favour the ferryl ion structure, or an isomer of this structure, for the higher oxidation state, and theHigher oxidation state may provisionally be named ferrylmyoglobin.
Journal ArticleDOI
An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.
TL;DR: Experiments with tritiated NADH are described which demonstrate that this "external" pathway of NADH oxidation resembles stereochemically the NADH-cytochrome c reductase system of liver microsomes, and differs from the respiratory chain-linked NADH dehydrogenase.
Book ChapterDOI
The respiratory chain and oxidative phosphorylation.
Britton Chance,G. R. Williams +1 more
TL;DR: How the respiratory chain and oxidative phosphorylation works and which substances may disable it are explained.
Journal ArticleDOI
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
TL;DR: Future investigation into the metabolism and biological functions of NAD and NADP may expose fundamental properties of life, and suggest new strategies for treating diseases and slowing the aging process.
Journal ArticleDOI
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses
TL;DR: If defective mitochondrial energy metabolism plays a role in cell death in neurodegenerative disorders, potential therapeutic strategies would be to use excitatory amino acid antagonists or agents to bypass bioenergetic defects.
References
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The extinction coefficients of the reduced band of pyridine nucleotides
B.L. Horecker,Arthur Kornberg +1 more
TL;DR: The quantitative determination of the pyridine nucleotides and of substrates which can be brought into stoichiometric reaction with them has been hampered by the lack of reliable extinction coefficients for these substances.
Journal ArticleDOI
Reversible enzymatic synthesis of diphosphopyridine nucleotide and inorganic pyrophosphate
TL;DR: An enzyme has now been purified from yeast and liver which catalyzes the reversible synthesis of DPN and PP according to equation (1), which shows that the production of inorganic pyrophosphate was not a result of simple hydrolysis of adenosine triphosphate (ATP).