Journal ArticleDOI
Plasma elastase levels in the adult respiratory distress syndrome
Lynne M. Zheutlin,Eugene J.-M.A. Thonar,Elizabeth R. Jacobs,Michael E. Hanley,Robert A. Balk,Roger C. Bone +5 more
TLDR
P 1 -protease inhibitor in patients with ARDS suggest that neutrophil release of this degradative enzyme may be pathophysiologically related to the pulmonary and multiorgan injury that characterizes this disorder.About:
This article is published in Journal of Critical Care.The article was published on 1986-03-01. It has received 23 citations till now. The article focuses on the topics: Elastase & ARDS.read more
Citations
More filters
Journal ArticleDOI
Current concepts of the inflammatory response after major trauma: an update
TL;DR: This review article highlights the current concepts of post-traumatic immunological changes and their impact in the management of trauma patients.
BookDOI
Pathophysiology of shock, sepsis, and organ failure
Günther Schlag,Heinz Redl +1 more
TL;DR: In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters.
Journal ArticleDOI
Plasma Elastase Levels and the Development of the Adult Respiratory Distress Syndrome
Seamas C. Donnelly,I R MacGregor,Adil Zamani,M. W. G. Gordon,Colin Robertson,D. J. Steedman,K. Little,Christopher Haslett +7 more
TL;DR: Findings reinforce the importance of neutrophils and their secretory products in early ARDS disease pathogenesis as manifested by elevated levels of immunoreactive neutrophil elastase in the peripheral blood.
Journal ArticleDOI
Effect of Almitrine on Ventilation-Perfusion Distribution in Adult Respiratory Distress Syndrome
TL;DR: Almitrine significantly reduced the VA/Q inequalities present in ARDS and may be useful in the management of those patients.
Journal ArticleDOI
Review: systemic effects of femoral nailing: from Küntscher to the immune reactivity era.
TL;DR: This review article focuses on the evidence that has emerged during the past century regarding the systemic effects of femoral nailing.
References
More filters
Journal ArticleDOI
Multiple Organ System Failure and Infection in Adult Respiratory Distress Syndrome
TL;DR: Vigorous evaluation and treatment of infection in patients with the adult respiratory distress syndrome may improve survival and be more common in infected patients than noninfected patients.
Journal ArticleDOI
Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome
TL;DR: It is concluded that in many patients with ARDS, high levels of neutrophil elastolytic activity in the lungs are associated with reduced alpha-1-AP function.
Journal ArticleDOI
Complement-induced granulocyte aggregation: an unsuspected mechanism of disease.
TL;DR: The capacity of blood cells to aggregate, best exemplified by the response of platelets to vascular injury, is generally thought to be beneficial, however, if aggregation occurs inappropriately—particularly if it involves large numbers of cells—it can be harmful.
Journal ArticleDOI
Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema.
TL;DR: Lower respiratory tract of non-smoking individuals with normal serum antiproteases and individuals with PiZ homozygous alpha 1-antitrypsin deficiency underwent bronchoalveolar lavage to evaluate the antiprotease screen of their lower respiratory tract, suggesting their vulnerability to neutrophil elastase is always present.
Journal ArticleDOI
Studies on the Pathogenesis of the Adult Respiratory Distress Syndrome
TL;DR: In BAL fluids from all 24 patients with ARDS, leukocytic elastase and/or alpha1-PI exist, and in some cases where active enzyme and alpha 1-PI coexisted, free, but inactive alpha2-PI was present, suggesting the presence of an enzyme-inhibitor complex.