Journal ArticleDOI
Polycystic ovarian disease
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This article is published in Fertility and Sterility.The article was published on 1981-04-01. It has received 292 citations till now. The article focuses on the topics: Polycystic ovarian disease.read more
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Journal ArticleDOI
Prevalence of the polycystic ovary syndrome in unselected Black and White women of the Southeastern United States : A prospective study
Eric S. Knochenhauer,Timothy J. Key,Melissa Kahsar-Miller,W. Waggoner,Larry R. Boots,Ricardo Azziz +5 more
TL;DR: In a consecutive population of unselected women the prevalence of hirsutism varied from 2-8% depending on the chosen cut-off F-G score, with no significant difference between White and Black women.
Journal ArticleDOI
Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease.
TL;DR: It is demonstrated that hyperandrogenism correlates with hyperinsulinism, and basal plasma total immunoreactive insulin, androstenedione, and testosterone in 14 obese women with polycystic ovarian disease are evaluated.
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Polycystic Ovary Syndrome
TL;DR: It is of interest to realize that polycystic ovary syndrome has moved from a histology diagnosis of ovarian tissue to a heterogeneous clinical syndrome, to a reproductive endocrine abnormality with elevated serum luteinizing hormone and androgen levels, and to a metabolic disease characterized by hyperinsulinemia and dyslipidemia.
Journal ArticleDOI
Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone
Judith M. Adams,D. W. Polson,N. A. Abdulwahid,David V. Morris,Stephen Franks,H. D. Mason,M. Tucker,Jackie F. Price,Howard S. Jacobs +8 more
TL;DR: In MFO ovarian morphology reverted to normal in ovulatory cycles, whereas in PCO the polycystic pattern persisted despite the presence of a dominant follicle, suggesting MFO may represent a normal ovarian response to weight-related hypothalamic disturbance of gonadotropin control.
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Insulin Stimulates Androgen Accumulation in Incubations of Ovarian Stroma Obtained from Women with Hyperandrogenism
Robert L. Barbieri,Anastasia Makris,Rebecca W. Randall,Gilbert H. Daniels,Robert W. Kistner,Kenneth J. Ryan +5 more
TL;DR: The studies suggest that human ovarian stroma may be a target tissue for insulin and IGF-I, and that hyperinsulinemia may be an important factor contributing to ovarian hyperandrogenism.
References
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Journal ArticleDOI
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.
TL;DR: In six patients with acanthosis nigricans variable degrees of glucose intolerance, hyperinsulinemia and marked resistance to exogenous insulin were found, studies of insulin receptors on circulating monocytes suggest that the insulin resistance in these patients was due to a marked decrease in insulin binding to its membrane receptors.
Journal ArticleDOI
Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease.
TL;DR: It is demonstrated that hyperandrogenism correlates with hyperinsulinism, and basal plasma total immunoreactive insulin, androstenedione, and testosterone in 14 obese women with polycystic ovarian disease are evaluated.
Journal ArticleDOI
Review article: the polycystic ovary syndrome
TL;DR: Current evidence regarding the basis for the dysfunction of ovarian steroidogenesis and follicular maturation, and the aberration of gonadotropin secretion as related to the inappropriate steroid feedback system will be reviewed.
Journal ArticleDOI
Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.
TL;DR: Data indicate that in these PCO patients the abnormalities of the hypothalamic-pituitary regulation of gonadotropin secretion was not an inherent defect but represented a functional derangement consequent to inappropriate estrogen feedback, which led to a vicious cycle of chronic anovulation and inappropriate gonadotropic secretion.
Journal ArticleDOI
The Microenvironment of the Human Antral Follicle: Interrelationships among the Steroid Levels in Antral Fluid, the Population of Granulosa Cells, and the Status of the Oocyte in Vivo and in Vitro
TL;DR: It is tentatively suggested that follicles with a potential for further development are those with more than 50‰ of their full complement of granulosa cells for their respective diameters, and high concentrations of 17β-estradiol in their antral fluid.