Journal ArticleDOI
Potential for increasing the differential response between tumors and normal tissues: Can proliferation rate be used?☆
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TLDR
Evidence is presented that the effective doubling times of clonogenic cells in human tumors during multifraction radiotherapy are in the range of a few days, that is, similar to the pre-treatment Potential Doubling Times and much shorter than Volume Doubling times.Abstract:
Rapid proliferation of malignant cells has not previously been emphasized as a major source of failure to control tumors. Evidence is presented that the effective doubling times of clonogenic cells in human tumors during multifraction radiotherapy are in the range of a few days, that is, similar to the pre-treatment Potential Doubling Times and much shorter than Volume Doubling Times. Evidence from animal tumor studies leads to the same conclusion. Accelerated fractionation should be considered for individual human tumors whose LI is measured (e.g., by flow cytometry and the BUR antibody) and found to be high.read more
Citations
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Journal ArticleDOI
Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Loss of local control with prolongation in radiotherapy
Jack F. Fowler,Mary J. Lindstrom +1 more
TL;DR: It is clear that modest prolongation is associated with a lower chance of local control, and the magnitude of time factors relating local control to overall time is determined.
Journal ArticleDOI
Carcinoma of the uterine cervix. I: Impact of prolongation of overall treatment time and timing of brachytherapy on outcome of radiation therapy
TL;DR: In multivariate analysis of patients with Stage IB and IIA, OTT and clinical stage were the most important prognostic factors for pelvic tumor control, disease-free survival, and CSS, and tumor size was a prognostic factor for CSS.
Journal ArticleDOI
Fractionation in radiotherapy.
L. Moonen,Harry Bartelink +1 more
TL;DR: Baclesse, who succeeded Coutard at the lnstitut Curie, demonstrated that the fraction size rather than the dose rate had the greatest influence on the intensity of acute skin reactions, which forms the basis of what is presently called ‘conventional’ fractionation.
Journal ArticleDOI
Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry.
George S. Wilson,N. J. McNally,Stanley Dische,M.I. Saunders,C. Des Rochers,A. A. Lewis,M.H. Bennett +6 more
TL;DR: The striking feature of the study was that 38% of the tumours had a potential doubling time of 5 days or less, and there was no relationship between proliferation and histopathological differentiation or DNA ploidy.
References
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Journal ArticleDOI
Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
TL;DR: Monoclonal antibodies specific for 5-bromodeoxyuridine have been produced and applied in detecting low levels of DNA replication on a cell-by-cell basis in vitro and do not cross-react with thymidine.
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Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships
TL;DR: These findings imply that the shape of the dose-survival curve for the target cells whose depletion results in late effects is different from that for target cells for acute effects: as the dose increases the contribution to cell killing from accumulated sublethal injury, relative to killing from single hit events, increases more rapidly in thetarget cells for late effects.
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A method to measure the duration of DNA synthesis and the potential doubling time from a single sample.
TL;DR: A method is described whereby the DNA synthesis time, Ts, can be calculated using data of a single sample of cells taken several hours after labelling with bromodeoxyuridine, and reasonable agreement was seen with published estimates of Ts for these tissues.
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Growth Kinetics of Tumours
TL;DR: This book reviews a workshop held in Geneva in 1977 to discuss the pathogenesis of human breast cancer in relation to hormonal status, immunologic status and possible viral aetiology, and points to future areas of potential interest in viral and hormonal pathogenesis and host immuno-reactivity.
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Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: analysis of 101 published survival curves.
B Fertil,Edmond-Philippe Malaise +1 more
TL;DR: It was found that cells from tumors with low radioresponsiveness (melanomas and glioblastomas) are the less radiosensitive, and the range of survival at a dose of 2 Gy is broad enough to account, in large measure, for observed differences in clinical tumor radiore sponsorship.