Journal ArticleDOI
Premorbid abnormalities in mania, schizomania, acute schizophrenia and chronic schizophrenia.
TLDR
It is concluded that the prevalence of premorbid abnormalities is highest among chronic schizophrenia, but similar disturbances also occur, to a lesser degree, in less disabling affective and non-affective psychotic disorders.Abstract:
The aim of this study was to examine the hypothesis that differences in outcome among affective and non-affective psychoses are associated with differences in the degree of developmental deviance. We conducted a retrospective survey of first contact cases treated over a 20-year period in a psychiatric hospital serving a catchment area in South London. All patients with non-depressive functional psychoses residing in the catchment area who received their first psychiatric treatment between 1965 and 1984 were included in the study. Cases were classified according to the relative chronicity of their illness into four non-overlapping groups: mania, schizomania, acute schizophrenia and chronic schizophrenia. There was a linear trend in the association between illness chronicity and proxy measures of developmental deviance, such as premorbid unemployment, single status and poor academic achievement. Compared to individuals with mania, schizophrenic patients had a 3–6 times increased risk of premorbid abnormality. For patients with schizomania and acute schizophrenia, the risk was 1.5–3 times greater than for manic subjects. We conclude that the prevalence of premorbid abnormalities is highest among chronic schizophrenia, but similar disturbances also occur, to a lesser degree, in less disabling affective and non-affective psychotic disorders.read more
Citations
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Journal ArticleDOI
A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder.
Abraham Reichenberg,Mark Weiser,Jonathan Rabinowitz,Asaf Caspi,James Schmeidler,Mordechai Mark,Zeev Kaplan,Michael H. Davidson +7 more
TL;DR: A nosologic distinction between nonpsychotic bipolar disease and schizophrenia in hospitalized patients is supported, supported by the results of a premorbid intellectual, language, and behavioral functioning comparison.
Journal ArticleDOI
Premorbid social functioning in schizophrenia and bipolar disorder: similarities and differences.
Mary Cannon,Peter B. Jones,Catherine Gilvarry,Larry Rifkin,Kwame McKenzie,A. Foerster,Robin M. Murray +6 more
TL;DR: The data support the view that poor premorbid social adjustment is one manifestation of vulnerability to adult psychotic disorders and are consistent with other findings pointing to early developmental deficits in patients who subsequently develop psychosis.
Book ChapterDOI
Serotonin and brain development.
TL;DR: The role of the serotonergic system in the neuroplastic events that create, repair, and degenerate the brain has been explored but the mechanisms for their therapeutic efficacy are still unclear.
Journal ArticleDOI
Discrimination and delusional ideation
I.C.M. Janssen,Manon Hanssen,Maarten Bak,R.V. Bijl,R. de Graaf,Wilma A. M. Vollebergh,Kwame McKenzie,J. van Os +7 more
TL;DR: In this paper, a 3-year prospective study of cohorts with no history of psychosis and differential rates of reported discrimination on the basis of age, gender, disability, appearance, skin colour or ethnicity and sexual orientation was conducted in the Dutch general population (n=4076).
Journal ArticleDOI
Developmental Precursors of Affective Illness in a General Population Birth Cohort
TL;DR: The findings give credence to the suggestion that affective disorder, especially its early-onset form, is preceded by impaired neurodevelopment.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
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Weight in infancy and death from ischaemic heart disease.
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Book
Dementia praecox and paraphrenia
TL;DR: "Dementia Praecox and Paraphrenia" (1919) was the book in which Kraepelin first presented his work on schizophrenia to the English-speaking world, and it was probably the most influential psychiatric text of the entire 20th century, and has now become rare.