Journal ArticleDOI
Preservation of ipsilateral submandibular gland is Ill advised in cancer of the floor of the mouth or tongue
Martin Lanzer,Thomas Gander,Heinz-Theo Lübbers,Philipp Metzler,Marius Bredell,Sabine Reinisch +5 more
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TLDR
The aim of this study was to assess the benefit of the preservation of the SMG and the associated risk of recurrent disease in patients with oropharyngeal or oral cavity squamous cell carcinoma.Abstract:
Objectives/Hypothesis
Preservation of the submandibular gland (SMG) during a neck dissection is gaining popularity and is showing an increasing tendency. The potential benefit, if the SMG is preserved, can be manifold. The aim of this study was to assess the benefit of the preservation of the SMG and the associated risk of recurrent disease in patients with oropharyngeal or oral cavity squamous cell carcinoma.
Study Design
Retrospective data analysis of 168 patients, with a follow-up of at least 3 years.
Methods
Log-rank test, univariate, and multivariate data analyses and P values for prediction of the excision of SMG on overall-, recurrence free-, and lymph node recurrence free survival.
Results
In patients with cancer of the floor of the mouth or tongue, lymph node recurrence-free survival was highly influenced by excision of the SMG (P < 0.001) and occurred in 28.5% of patients in whom the SMG was preserved. In all other tumor sites of the oral cavity and oropharyngeal region, excision of the SMG did not influence lymph node recurrence-free survival (P = 0.455).
Conclusions
Patients with squamous cell carcinoma (SCC) of the oral cavity or oropharyngeal region will benefit from preservation of the ipsilateral SMG. This is not true for patients with SCC of the surrounding tissue nearest the SMG (i.e., floor of the mouth or the tongue). In such patients, the SMG must be excised.
Level of Evidence
4. Laryngoscope, 124:2070–2074, 2014read more
Citations
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Journal ArticleDOI
Safety and efficacy of concurrent neck dissection and transoral robotic surgery
Cüneyt Kucur,Kasim Durmus,Ramazan Gun,Matthew O. Old,Amit Agrawal,Theodoros N. Teknos,Enver Ozer +6 more
TL;DR: This study evaluates the safety and efficacy of concurrent neck dissection in oropharyngeal squamous cell carcinoma treated with TORS.
Journal ArticleDOI
Incidence of intraglandular lymph nodes within submandibular gland, and involvement by floor of mouth cancer.
TL;DR: Despite the high incidence of level I metastasis in floor of mouth, lymphatic metastases to submandibular gland are unlikely based on absence of intraglandular lymph nodes, and a previously unreported mechanism of submandIBular gland involvement is described.
Is it necessary to remove submandibular glands in squamous cell carcinomas of the oral cavity? È necessaria l'asportazione chirurgica delle ghiandole sottomandibolari nel carcinoma squamoso del cavo orale?
TL;DR: The authors investigated and analyzed the retrospective charts of 236 patients who underwent surgery for OCSCC over a 10-year period and the pathology reports of 294 neck dissections with SMG removal to determine the frequency and the mechanism of submandibular gland involvement in oral cavity squamous cell carcinomas.
Journal ArticleDOI
Prospective study of the pattern of lymphatic metastasis in relation to the submandibular gland in patients with carcinoma of the oral cavity.
Akshat Malik,Poonam Joshi,Aseem Mishra,Apurva Garg,Manish Mair,Swagnik Chakrabarti,Sudhir Nair,Deepa Nair,Pankaj Chaturvedi +8 more
TL;DR: Whether submandibular gland preservation is a viable option in patients with carcinoma of the oral cavity is tried to find out.
Journal ArticleDOI
Submandibular Gland Invasion by Oral Cavity Cancers: A Systematic Review.
TL;DR: Given this rarity of SMG involvement, preservation of SMGs might be feasible in selected patient population, however, additional studies need to examine the functionality of preserved SMGs among patients who receive postoperative adjuvant radiation therapy.
References
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A review of saliva: Normal composition, flow, and function
TL;DR: A brief, up-to-date overview of the literature on the basics of normal salivary composition, flow, and function is provided.
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Excision of Cancer of the Head and Neck: With Special Reference to the Plan of Dissection Based on One Hundred and Thirty-two Operations
TL;DR: This paper is intended to present an outline sketch of the conclusions regarding the surgical treatment of cancer of the head and neck in the curable stage, and the immediate extension from the primary focus is principally excision.
Journal ArticleDOI
Significance of positive margins in oral cavity squamous carcinoma
Thom R. Loree,Elliot W. Strong +1 more
TL;DR: The importance of adequate resection of the primary tumor as well as the relative ineffectiveness of adjuvant postoperative radiotherapy in the improvement of local control in patients with positive surgical margins are confirmed.
Journal ArticleDOI
Surgical margin determination in head and neck oncology: Current clinical practice. The results of an International American Head and Neck Society Member Survey†
TL;DR: The aim was to investigate the ways in which surgeons who perform head and neck ablative procedures on a regular basis define margins, how they use frozen sections to evaluate margins, and the effect of chemoradiation on determining tumor margins.
Journal ArticleDOI
Morbidity associated with removal of the submandibular gland
TL;DR: Postoperative complications in 206 submandibular gland excisions, excluding those resulting from benign or malignant tumours, carried out during a 15-year period were reviewed, and in those cases with a permanent neurological deficit, the facial nerve was the most often affected.