Journal ArticleDOI
Pressure pain thresholds in different tissues in one body region. The influence of skin sensitivity in pressure algometry.
Eva Kosek,Jan Ekholm,Per Hansson +2 more
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TLDR
Under the given circumstances, skin pressure pain sensitivity was demonstrated to influence the PPT and EMLA cream increased PPTs compared to control sites in all examined areas.Abstract:
This study aimed at determining whether there are differences in pressure pain sensitivity in different tissues in the same body region when systematically assessed, before and after skin hypoesthesia. Pressure pain thresholds (PPTs) were assessed bilaterally in 15 healthy females at the bony part of the epicondylus lateralis humeri, at the belly of m. extensor carpi ulnaris and at m. brachioradialis where the superficial radial nerve branches pass underneath ("muscle/nerve" site). Following a double blind design, a local anaesthetic cream (EMLA) or a control cream was applied to the skin and PPTs were reassessed. The PPT was significantly (p < 0.001) lower at the "muscle/nerve" site than at the bony and "pure" muscle sites. The PPTs over the bony and "pure" muscle sites did not differ. There was no significant difference when PPTs were compared before and after application of EMLA cream. However, PPTs after control cream were lower (p < 0.001) over all examined areas than those obtained prior to cream application. Thus, EMLA cream increased PPTs compared to control sites in all examined areas (p < 0.001). Under the given circumstances, skin pressure pain sensitivity was demonstrated to influence the PPT.read more
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Journal ArticleDOI
Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values
Roman Rolke,Ralf Baron,Christoph Maier,Thomas R. Tölle,Rolf-Detlef Treede,Antje Beyer,Andreas Binder,Niels Birbaumer,Frank Birklein,I. C. Bötefür,S. Braune,Herta Flor,Volker Huge,R. Klug,G. B. Landwehrmeyer,Walter Magerl,Christian Maihöfner,C. Rolko,C. Schaub,Andrea Scherens,Till Sprenger,Michael Valet,B. Wasserka +22 more
TL;DR: Application of this standardized QST protocol in patients and human surrogate models will allow to infer underlying mechanisms from somatosensory phenotypes as well as judge plus or minus signs in patients.
Journal ArticleDOI
Quantitative sensory testing: a comprehensive protocol for clinical trials
Roman Rolke,Walter Magerl,K. Andrews Campbell,C. Schalber,S. Caspari,Frank Birklein,Rolf-Detlef Treede +6 more
TL;DR: A comprehensive QST protocol is compiled using well established tests for nearly all aspects of somatosensation to test for patterns of sensory loss or gain, and to assess both cutaneous and deep pain sensitivity.
Journal ArticleDOI
Interrater reliability of algometry in measuring pressure pain thresholds in healthy humans, using multiple raters
TL;DR: This study provides new evidence that trained observers can apply an algometer at a consistent rate and provide highly reliable measures of PPT in healthy humans, when PPT is calculated as the mean of 3 trials.
Journal ArticleDOI
Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief.
Eva Kosek,Gunnar Ordeberg +1 more
TL;DR: No pressure pain modulation was induced by HNCS in patients before surgery, as opposed to controls, suggesting a dysfunction in systems subserving ‘diffuse noxious inhibitory controls’ (DNIC).
Journal ArticleDOI
Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain
Stefan Lautenbacher,Miriam Kunz,Miriam Kunz,Peter Strate,Jesper Ellerbæk Nielsen,Lars Arendt-Nielsen +5 more
TL;DR: Evidence is provided for stimulus‐specific changes in pain perception in the elderly, with deep tissue (muscle) nociception being affected differently by age than superficial tissue (skin) nOCiception and Summation mechanisms contribute only moderately to age changes inPain perception.
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