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This article is published in Journal of the American Optometric Association.The article was published on 1983-04-01 and is currently open access. It has received 483 citations till now.read more
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Journal ArticleDOI
Role of Oxidative Stress in Development of Complications in Diabetes
TL;DR: Structural characterization of the cross-links and other products accumulating in collagen in diabetes is needed to gain a better understanding of the relationship between oxidative stress and the development of complications in diabetes.
Journal ArticleDOI
Five-Year Follow-Up After Clinical Islet Transplantation
Edmond A. Ryan,Breay W. Paty,Peter A. Senior,David L. Bigam,Eman Alfadhli,Norman M. Kneteman,Jonathan R. T. Lakey,A. M. James Shapiro +7 more
TL;DR: In conclusion, islet transplantation can relieve glucose instability and problems with hypoglycemia and point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression.
Journal ArticleDOI
How malaria has affected the human genome and what human genetics can teach us about malaria.
TL;DR: The challenge for the next decade is to build the global epidemiological infrastructure required for statistically robust genomewide association analysis, as a way of discovering novel mechanisms of protective immunity that can be used in the development of an effective malaria vaccine.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept
TL;DR: AGEs elicit a wide range of cell-mediated responses that might contribute to the pathogenesis of diabetic complications, vascular and renal disease and Alzheimer's disease and Substances that inhibit AGE formation, reduce oxidative stress or destroy already formed crosslinks may limit the progression of disease.
References
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Journal ArticleDOI
Role of Oxidative Stress in Development of Complications in Diabetes
TL;DR: Structural characterization of the cross-links and other products accumulating in collagen in diabetes is needed to gain a better understanding of the relationship between oxidative stress and the development of complications in diabetes.
Journal ArticleDOI
Five-Year Follow-Up After Clinical Islet Transplantation
Edmond A. Ryan,Breay W. Paty,Peter A. Senior,David L. Bigam,Eman Alfadhli,Norman M. Kneteman,Jonathan R. T. Lakey,A. M. James Shapiro +7 more
TL;DR: In conclusion, islet transplantation can relieve glucose instability and problems with hypoglycemia and point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression.
Journal ArticleDOI
How malaria has affected the human genome and what human genetics can teach us about malaria.
TL;DR: The challenge for the next decade is to build the global epidemiological infrastructure required for statistically robust genomewide association analysis, as a way of discovering novel mechanisms of protective immunity that can be used in the development of an effective malaria vaccine.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept
TL;DR: AGEs elicit a wide range of cell-mediated responses that might contribute to the pathogenesis of diabetic complications, vascular and renal disease and Alzheimer's disease and Substances that inhibit AGE formation, reduce oxidative stress or destroy already formed crosslinks may limit the progression of disease.