Open AccessJournal Article
Primary antiphospholipid syndrome
Angela Popa,Liliana Voinea,Monica Pop,Daniela Stana,Ana Maria Dascalu,Cristina Alexandrescu,Radu Ciuluvica +6 more
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TLDR
Primary APS occurs when there is no evidence of associated diseases, and APS in the presence of an underlying disease, usually systemic lupus erythematosus, is called secondary APS.Abstract:
Antiphospholipid syndrome (APS) is a disorder characterised by recurrent arterial or venous thrombosis and/or pregnancy losses, in the presence of persistently elevated levels of anticardiolipin antibodies and/or evidence of circulating lupus anticoagulant (these abnormalities are detected by blood tests). Primary APS occurs when there is no evidence of associated diseases. APS in the presence of an underlying disease, usually systemic lupus erythematosus, is called secondary APS.read more
Citations
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Journal ArticleDOI
The antiphospholipid syndrome: from pathophysiology to treatment
TL;DR: The objective of this review paper is to summarize the recent literature on APS from pathogenesis to current therapeutic options.
Journal ArticleDOI
Microvascular and microangiopathic antiphospholipid-associated syndromes ("MAPS"): semantic or antisemantic?
TL;DR: Small vessel occlusions may occur as part of the vascular manifestations of the Antiphospholipid Syndrome and may affect glomerular, skin, retinal, bowel, hepatic or pulmonary vessels, and the term "MAPS" is suggested for these two groups of conditions.
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Isolated IgA anti- β2 glycoprotein I antibodies in patients with clinical criteria for antiphospholipid syndrome.
Raquel Ruiz-García,Manuel Serrano,Jose Angel Martinez-Flores,Sergio Mora,Luis Morillas,María Ángeles Martín-Mola,José M. Morales,Estela Paz-Artal,Antonio Serrano +8 more
TL;DR: Assessment of aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other a-PL antibodies.
Journal ArticleDOI
Antiphospholipid syndrome and systemic lupus erythematosus: are they separate entities or just clinical presentations on the same scale?
TL;DR: A multiorgan involvement that cannot be explained by the thrombophilic state per se and similar to the well known clinical manifestations in lupus is reported in patients with primary antiphospholipid syndrome.
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Is there a microangiopathic antiphospholipid syndrome
TL;DR: Although large-vessel occlusions do occur in catastrophic APS, they do not dominate the clinical picture, and their frequency is completely different from that encountered in the classic APS itself.
References
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Journal ArticleDOI
Acute thrombotic occlusion of right coronary and left circumflex coronary arteries in a patient with antiphospholipid syndrome: successful stent implantation.
TL;DR: In the literature, this is the first case with antiphospholipid syndrome in which primary coronary angioplasty with stent implantation was successfully performed for two coronary arteries with acute thrombotic occlusion.
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News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination.
TL;DR: An update on the pathophysiological role of β2-GPI and a meta-analysis were conducted providing an overview of the current progress towards anti-β2- GPI detection.
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Role of anti-annexin A5 in pathogenesis of hypercoagulable state in patients with antiphospholipid syndrome.
TL;DR: This work studied role of aANX IgG in the pathogenesis of hypercoagulable state in APS patients and found it to have a role in pathophysiology of APS.
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Autoimmune intrahepatic cholangiopathy associated with antiphospholipid antibody syndrome.
Giuseppe Murdaca,Barbara Maria Colombo,Barbara Sprecacenere,Matteo Caiti,Massa G,Antonino Picciotto,Paola Ceppa,Francesco Puppo +7 more
TL;DR: To the authors' knowledge, this is the first description of a patient with an association of intrahepatic cholangiopathy and aPL, thus suggesting that autoimmune liver disease might associate with aPL syndrome.
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Immune Complexes of Beta-2-Glycoprotein I and IgA Antiphospholipid Antibodies Identify Patients With Elevated Risk of Thrombosis and Early Mortality After Heart Transplantation.
Manuel Serrano,Laura Morán,Jose Angel Martinez-Flores,Esther Mancebo,Daniel E Pleguezuelo,Oscar Cabrera-Marante,Juan Luis Delgado,Antonio Serrano +7 more
TL;DR: In kidney transplanted patients, B2A-CIC is a biomarker that predicts which patients IgA aB2GP1 positive are at risk of thrombosis events following kidney transplantation and may lead to early prophylactic treatment.