Principles of laboratory assessment of drug abuse liability and implications for clinical development.
TLDR
The current "gold standard" methodologies that are used for laboratory assessments of abuse liability in non-human and human subjects are described and particular emphasis is given to procedures such as non- human drug discrimination, self-administration, and physical dependence testing, and human dose-effect abuse liability studies that are commonly used in regulatory submissions to governmental agencies.About:
This article is published in Drug and Alcohol Dependence.The article was published on 2009-12-01 and is currently open access. It has received 182 citations till now. The article focuses on the topics: Substance abuse & Postmarketing surveillance.read more
Citations
More filters
Journal ArticleDOI
Electronic cigarettes: Effective nicotine delivery after acute administration.
TL;DR: Examination of the effects of ECs in experienced users who were using their preferred devices found increases in ratings of direct effects of nicotine and product were observed as well as decreases in abstinence symptoms.
Journal ArticleDOI
Waterpipe tobacco smoking and cigarette smoking: a direct comparison of toxicant exposure and subjective effects.
TL;DR: The findings are consistent with the conclusion that waterpipe tobacco smoking presents substantial risk of dependence, disease, and death, and they can be incorporated into prevention interventions that might help deter more adolescents and young adults from experimenting with an almost certainly lethal method of tobacco use.
Journal ArticleDOI
Serotonin 5-HT2 Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder
TL;DR: The present review will focus on the role of serotonin (5-HT; 5-hydroxytryptamine) neurotransmission in the neuropharmacology of cocaine and related abused stimulants and proposes new approaches to guide targeted development of serotonergic ligands for the treatment of cocaine use disorder.
Journal ArticleDOI
Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs
S. Stevens Negus,Laurence Miller +1 more
TL;DR: Strengths of ICSS in comparison with drug self-administration include potential for simultaneous evaluation of both abuse-related and abuse-limiting effects, flexibility for use with various routes of drug administration or drug vehicles, utility for studies in drug-naive subjects as well as in subjects with controlled levels of prior drug exposure, and utility for Studies of drug time course.
Journal ArticleDOI
The predictive validity of the rat self-administration model for abuse liability.
TL;DR: This review of 71 drugs identifies high concordance between findings from rat self-administration studies and two clinical indicators of abuse liability, namely reports of positive subjective-effects and the DEA drug scheduling status.
References
More filters
Journal ArticleDOI
Conditioned place preference: What does it add to our preclinical understanding of drug reward?
Michael T. Bardo,Rick A. Bevins +1 more
TL;DR: A theoretical overview of some critical issues relevant to conditioned place preference is provided and it seems clear that CPP measures a learning process that is fundamentally distinct from drug self-administration.
Journal ArticleDOI
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
TL;DR: This study suggests that it is unlikely that these central actions in man are a consequence of the release of norepinephrine in the brain, and suggests that these five agents share a common mode of central action.
Journal ArticleDOI
Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats
TL;DR: An operant behavioral study on morphine addiction utilized a self-injection technique for giving intravenous injections to relatively unrestrained rats, finding that Morphine was a reinforcer that produced almost immediate satiation.
Related Papers (5)
Principles of drug abuse liability assessment in laboratory animals.
Principles of initial experimental drug abuse liability assessment in humans
Conditioned place preference: What does it add to our preclinical understanding of drug reward?
Michael T. Bardo,Rick A. Bevins +1 more