Journal ArticleDOI
Production of peptide leukotrienes in endotoxin shock
TLDR
This demonstration of endotoxin‐induced generation of peptide LTs in vivo was possible by sequential HPLC and RIA analyses in bile into which peptide leukotriene are eliminated from blood.About:
This article is published in FEBS Letters.The article was published on 1985-01-28. It has received 116 citations till now. The article focuses on the topics: Leukotriene & Peptide.read more
Citations
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Journal ArticleDOI
Endotoxins and disease mechanisms
D C Morrison,J L Ryan +1 more
TL;DR: In this chapter, current concepts about the mechanisms of action of endotoxin are reviewed and particular attention is focused upon endotoxin-induced production of soluble mediators from macrophages and mononuclear cells and on the potential contribution of these mediators to endotoxin shock.
Journal ArticleDOI
A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase.
TL;DR: In mouse liver microsomes, NADPH-dependent aminopyrine dealkylation was totally inhibited in the presence of 50 mumol/1 PZ 51, and in vivo experiments with Se-deficient mice showed that the Se-moiety of Pz 51 is not available for the synthesis of the selenoenzyme GSH-Px after dietary treatment or i.p. doses up to 25 mg Se.
Journal ArticleDOI
Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.
TL;DR: It is concluded that PAF is produced in the lung during endotoxemia and may be an important mediator of the systemic and pulmonary hemodynamic changes as well as the acute lung vascular injury after endotoxinemia.
Journal ArticleDOI
Differential regulation of lipopolysaccharide-induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis.
TL;DR: In vitro data would suggest that the maintenance of elevated IL 1 levels coincident with the appearance of endogenous corticosteroids during LPS shock is related to the synthesis of IL 1 by both monocyte‐macrophages and non‐myeloid cell populations including endothelial cells.
Journal ArticleDOI
Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice.
TL;DR: It is concluded that tumor necrosis factor alpha is likely to act as a final mediator of endotoxin action in a sequence of events which includes formation of leukotriene D4 and reactive oxygen species.
References
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Journal ArticleDOI
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation
TL;DR: Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions.
Journal ArticleDOI
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response
Sven-Erik Dahlén,J Björk,Per Hedqvist,K E Arfors,Sven Hammarström,Jan Åke Lindgren,Bengt Samuelsson +6 more
TL;DR: It is suggested that leukotrienes, formed in several blood-borne and tissue-bound cells, may mediate important microcirculatory adjustments to noxious stimuli.
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Arachidonic Acid Metabolism in Polymorphonuclear Leukocytes: Effects of Ionophore A23187
Pierre Borgeat,Bengt Samuelsson +1 more
TL;DR: The data demonstrate that, in addition to causing release of endogenous substrate, the ionophore also activated the enzymatic system involved in the further transformations of arachidonic acid.
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The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.
R A Lewis,K F Austen +1 more
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Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro
Jeffrey M. Drazen,K F Austen,Robert A. Lewis,David Alan Clark,G. Goto,Anthony Marfat,E. J. Corey +6 more
TL;DR: In vivo, LTC-1 and LTD were nearly equally active in their effects on pulmonary mechanics, and the pattern of alterations was consistent with the predominant site of action being in the lung periphery, and these compounds are likely to be major mediators of the pathologic alterations in immediate type hypersensitivity reactions in which peripheral airway constriction and hypotension are prominent features.