Open AccessJournal Article
Prolactin and gonadal hormones during pregnancy in systemic lupus erythematosus.
L Jara-Quezada,A Graef,C Lavalle +2 more
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TLDR
It is concluded that gonadal hormones and PRL changes observed in SLE are present also during pregnancy and may be related to fetal wastage and reactivation of disease.Abstract:
We performed prospective hormonal studies in 9 patients (5 active and 4 inactive) with systemic lupus erythematosus (SLE) during pregnancy (Weeks 10 to 37) Nine healthy pregnant women and 5 patients with rheumatoid arthritis (RA) were used for comparison Serum prolactin (PRL), testosterone and estradiol (E2) levels were determined by RIA The patients with SLE showed higher serum PRL levels, the difference being statistically significant at Week 20, and reaching the highest levels at Weeks 30 to 40 (p = 005 when compared to healthy pregnant women) The 5 patients with active SLE had the highest serum PRL levels; one of these had fetal wastage In active SLE the serum testosterone and E2 levels were decreased significantly from Weeks 10 to 30 compared with controls (p = 0001) In patients with RA serum PRL levels, although higher than in controls, did not differ significantly, nor did the lower testosterone and E2 levels We conclude that gonadal hormones and PRL changes observed in SLE are present also during pregnancy and may be related to fetal wastage and reactivation of diseaseread more
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Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies
Guillermo Ruiz-Irastorza,F. Lima,José Delgado Alves,Munther A. Khamashta,Julie A. Simpson,G. R. V. Hughes,N. M. M. Buchanan +6 more
TL;DR: It is concluded that SLE tends to flare during pregnancy, maximal during the second and third trimester and the puerperium, and most of the flares can be managed conservatively.
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Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus.
TL;DR: Pregnancy induces a shift from TH1 to TH2 immune response, increasing the anti‐inflammatory cytokines IL‐4 and IL‐10, which may contribute to gestational amelioration of RA and trigger SLE manifestations that are dependent on humoral immune responses such as lupus nephritis.
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Gender differences in skin: a review of the literature.
Harry Dao,Rebecca A. Kazin +1 more
TL;DR: Advances in understanding of gender differences in skin will enable us to learn more about disease pathogenesis, with the goal of offering better treatments, and there is already a strong foundation on which to base future investigations.
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Hyperprolactinemia in Systemic Lupus Erythematosus: Association with Disease Activity
Luis J. Jara,Celso E. Gomez-Sanchez,Luis H. Silveira,Pindaro Martinez-Osuna,Frank B. Vasey,Luis R. Espinoza +5 more
TL;DR: Findings suggest a potential role for this immunoregulatory hormone in SLE pathogenesis and suggest a direct correlation with clinical disease and serological (ANA) activity was found.