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G. R. V. Hughes

Researcher at St Thomas' Hospital

Publications -  214
Citations -  10699

G. R. V. Hughes is an academic researcher from St Thomas' Hospital. The author has contributed to research in topics: Antiphospholipid syndrome & Lupus erythematosus. The author has an hindex of 52, co-authored 214 publications receiving 10416 citations.

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Journal Article

Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.

E. N. Harris, +3 more
- 01 Apr 1987 - 
TL;DR: This study shows that properly performed ELISA or SRIA assays can be used to provide an accurate, reproducible, and quantitative measure of IgG and IgM aCL concentration in serum samples.
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Morbidity and mortality in systemic lupus erythematosus during a 5-year period - A multicenter prospective study of 1,000 patients

Ricard Cervera, +16 more
- 01 May 1999 - 
TL;DR: Several immunologic parameters (anti-dsDNA or antiphospholipid antibodies) were found to have a predictive value for the development of SLE manifestations during the period of the study.
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Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies

Guillermo Ruiz-Irastorza, +6 more
- 01 Feb 1996 - 
TL;DR: It is concluded that SLE tends to flare during pregnancy, maximal during the second and third trimester and the puerperium, and most of the flares can be managed conservatively.
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Endothelial cells as target for antiphospholipid antibodies : Human polyclonal and monoclonal anti-β2-glycoprotein I antibodies react in vitro with endothelial cells through adherent β2-glycoprotein I and induce endothelial activation

N. Del Papa, +10 more
- 01 Mar 1997 - 
TL;DR: These findings support the hypothesis that anti-beta 2 GPI antibodies bind and activate EC through the adherent cofactor beta 2 G PI, likely leading to a procoagulant state.
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ANTIPHOSPHOLIPID ANTIBODIES AFFECT TROPHOBLAST GONADOTROPIN SECRETION AND INVASIVENESS BY BINDING DIRECTLY AND THROUGH ADHERED β2-GLYCOPROTEIN I

N. Di Simone, +12 more
- 01 Jan 2000 - 
TL;DR: It is suggested that aPL recognition of both anionic PL and adhered beta2GPI on trophoblast cell structures might represent a potential pathogenetic mechanism for defective placentation in women with the antiphospholipid syndrome.