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Journal ArticleDOI

Public Drinking Water Contamination and Birth Outcomes

TLDR
The effects of public drinking water contamination on birth outcomes were evaluated in an area of northern New Jersey and it cannot resolve whether the drinking water contaminants caused the adverse birth outcomes; therefore, these findings should be followed up utilizing available drinkingWater contamination databases.
Abstract
The effects of public drinking water contamination on birth outcomes were evaluated in an area of northern New Jersey. After excluding plural births and chromosomal defects, 80,938 live births and 594 fetal deaths that occurred during the period 1985-1988 were studied. Information on birth outcome status and maternal risk factors was obtained from vital records and the New Jersey Birth Defects Registry. Monthly exposures during pregnancy were estimated for all births using tap water sample data. Odds ratios of > or = 1.50 were found for the following: total trihalomethanes with small for gestational age, central nervous system defects, oral cleft defects, and major cardiac defects; carbon tetrachloride with term low birth weight, small for gestational age, very low birth weight, total surveillance birth defects, central nervous system defects, neural tube defects, and oral cleft defects; trichloroethylene with central nervous system defects, neural tube defects, and oral cleft defects; tetrachloroethylene with oral cleft defects; total dichloroethylenes with central nervous system defects and oral cleft defects; benzene with neural tube defects and major cardiac defects; and 1,2-dichloroethane with major cardiac defects. Total trihalomethane levels > 100 ppb reduced birth weight among term births by 70.4 g. By itself, this study cannot resolve whether the drinking water contaminants caused the adverse birth outcomes; therefore, these findings should be followed up utilizing available drinking water contamination databases.

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Journal ArticleDOI

Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research.

TL;DR: The brominated DBPs were the most genotoxic of all but have not been tested for carcinogenicity and highlighted the emerging importance of dermal/inhalation exposure to the THMs, or possibly other DBPs, and the role of genotype for risk for drinking-water-associated bladder cancer.
Journal ArticleDOI

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge: A Scientific Statement From the American Heart Association Council on Cardiovascular Disease in the Young

TL;DR: In this article, the authors summarized the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects and highlighted definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis.
Journal ArticleDOI

Natural gas from shale formation – The evolution, evidences and challenges of shale gas revolution in United States

TL;DR: The history of US shale gas in this article is divided into three periods and based on the change of oil price (i.e., the period before the 1970s oil crisis, the period from 1970s to 2000, and the period since 2000), the US has moved from being one of the world's biggest importers of gas to being selfsufficient in less than a decade, with the shale gas production increasing 12fold (from 2000 to 2010).
Journal ArticleDOI

Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review

TL;DR: To identify the specific components that may be of aetiological concern and hence to fit the most appropriate exposure model with which to investigate human exposure to chlorinated DBPs, further detailed toxicological assessments of the mixture of byproducts commonly found in drinking water are also needed.
Journal ArticleDOI

Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants

TL;DR: This review summarizes the level of epidemiologic evidence for relationships between prenatal and/or early life exposure to environmental chemical contaminants and fetal, child, and adult health and points to three main needs.
References
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Book

Statistical Inference

Journal ArticleDOI

No adjustments are needed for multiple comparisons.

Kenneth J. Rothman
- 01 Jan 1990 - 
TL;DR: A policy of not making adjustments for multiple comparisons is preferable because it will lead to fewer errors of interpretation when the data under evaluation are not random numbers but actual observations on nature.

Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.

N. E. Breslow, +1 more
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Journal ArticleDOI

Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel-Haenszel Procedure

TL;DR: In this article, a method for analyzing multiple 2×2 contingency tables arising in retrospective studies of disease is extended in application and form, which includes comparisons of age-adjusted death rates, life-table analyses, comparisons of two sets of quantal dosage response data, and miscellaneous laboratory applications as appropriate.
Journal ArticleDOI

Computing an Exact Confidence Interval for the Common Odds Ratio in Several 2×2 Contingency Tables

TL;DR: A quadratic time network algorithm is provided for computing an exact confidence interval for the common odds ratio in several 2×2 independent contingency tables, shown to be a considerable improvement on an existing algorithm developed by Thomas (1975), which relies on exhaustive enumeration.
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