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QT dispersion: an indication of arrhythmia risk in patients with long QT intervals.

Christopher P. Day, +2 more
- 01 Jun 1990 - 
- Vol. 63, Iss: 6, pp 342-344
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TLDR
In patients with prolonged QT intervals, QT dispersion distinguished between those with ventricular arrhythmias and those without, which supports the hypothesis that Qt dispersion reflects spatial differences in myocardial recovery time.
Abstract
Homogeneity of recovery time protects against arrhythmias whereas dispersion of recovery time is arrhythmogenic. A single surface electrocardiographic QT interval gives no information on recovery time dispersion but the difference between the maximum and minimum body surface QT interval may be relevant. This hypothesis was tested by measuring the dispersion of the corrected QT interval (QTc) in 10 patients with an arrhythmogenic long QT interval (Romano Ward and Jervell and Lange-Nielsen syndromes or drug arrhythmogenicity) and in 14 patients without arrhythmias in whom the QT interval was prolonged by sotalol. QTc dispersion was significantly greater in the arrhythmogenic QT group than in the sotalol QT group. In patients with prolonged QT intervals, QT dispersion distinguished between those with ventricular arrhythmias and those without. This supports the hypothesis that QT dispersion reflects spatial differences in myocardial recovery time. QT dispersion may be useful in the assessment of both arrhythmia risk and the efficacy of antiarrhythmic drugs.

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Citations
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Journal ArticleDOI

AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology.

TL;DR: The present article introduces the second part of “Recommendations for Standardization and Interpretation of the Electrocardiogram”, a project initiated by the Council on Clinical Cardiology of the American Heart Association and endorsed by the American College of Cardiology.
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Sudden death due to cardiac arrhythmias.

TL;DR: This review article summarizes important changes in the approach to the serious public health problem of sudden death from ventricular arrhythmias.
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AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram

TL;DR: The fourth in a series of 6 documents focused on providing current guidelines for the standardization and interpretation of the electrocardiogram (ECG) was published by the American Heart Association as discussed by the authors.
Journal ArticleDOI

Qt dispersion and sudden unexpected death in chronic heart failure

TL;DR: The association of increased QT dispersion with sudden death suggests that patients at high risk of such death could be identified by means of this simple, reproducible test.
Journal ArticleDOI

AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram. Part III: Intraventricular Conduction Disturbances A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society

TL;DR: The present article is the fourth in a series of 6 documents focused on providing current guidelines for the standardization and interpretation of the electrocardiogram (ECG) and explains why the ST and TP segments are normally nearly flat and at approximately the same level; that is, they are isoelectric.
References
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Journal Article

An analysis of the time-relations of electrocardiograms

TL;DR: In this paper, a preliminary attempt was made to determine from blood pressure records the relative influence of the heart action and of vaso-canstriction, and it was suggested that it might be necessary to estimate the duration of ventricular systole for different heart rates.
Journal ArticleDOI

Confidence intervals rather than P values: estimation rather than hypothesis testing.

Martin J. Gardner, +1 more
- 15 Mar 1986 - 
TL;DR: Some methods of calculating confidence intervals for means and differences between means are given, with similar information for proportions, and the paper also gives suggestions for graphical display.
Journal ArticleDOI

Nonuniform Recovery of Excitability in Ventricular Muscle

Jaok Han, +1 more
- 01 Jan 1964 - 
TL;DR: The degree of dispersion following a basic beat was increased by stimulation of the cardiac sympathetic nerves, administration of chloroform, ouabain intoxication, and administration of higher doses of quinidine, myocardial ischemia, and hypothermia, but it was decreased by administration of sympathomimetic amines.
Journal ArticleDOI

Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations.

TL;DR: The results show that the large dispersion of repolarization facilitates the development of a conduction delay necessary to induce sustained arrhythmia by an early premature stimulus applied at the site with a short MAP.
Journal ArticleDOI

QT interval prolongation as predictor of sudden death in patients with myocardial infarction.

TL;DR: It is concluded that a constant prolongation of QTc in patients with myocardial infarction may help, with other risk factors, in defining a subgroup at higher risk for sudden death.
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