Randomized Comparison of 2 Hydration Regimens in 1620 Patients Undergoing Coronary Angioplasty

TLDR: In this paper, a total of 1620 patients were assigned to receive isotonic (n =8 09) or half-isotonic hydration, and a primary end point analysis was possible in 1383 patients.

Abstract: Results: A total of 1620 patients were assigned to receive isotonic (n =8 09) or half-isotonic (n =8 11) hydration. Primary end point analysis was possible in 1383 patients. Baseline characteristics were well matched. Contrast media–associated nephropathy was significantly reduced with isotonic (0.7%, 95% confidence interval, 0.1%-1.4%) vs half-isotonic (2.0%, 95% confidence interval, 1.0%-3.1%) hydration (P = .04). Three predefined subgroups benefited in particular from isotonic hydration: women, persons with diabetes, and patients receiving 250 mL or more of contrast. The incidence of cardiac (isotonic, 5.3% vs half-isotonic, 6.4%; P=.59) and peripheral vascular (isotonic, 1.6% vs half-isotonic, 1.5%, P = .93) complications was similar between the 2 hydration groups.