Journal ArticleDOI
Reactivity of Nucleophilic Reagents toward Esters
William P. Jencks,Joan Carriuolo +1 more
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This article is published in Journal of the American Chemical Society.The article was published on 1960-04-01. It has received 340 citations till now. The article focuses on the topics: Acid hydrolysis & Reactivity (chemistry).read more
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Journal ArticleDOI
The biochemistry and medical significance of the flavonoids.
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
Journal ArticleDOI
Catalytic promiscuity and the evolution of new enzymatic activities
TL;DR: Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.
Journal ArticleDOI
Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems
TL;DR: Studies from the laboratory are summarized using the H(2)O(2)-mediated oxidation of aryl boronates to phenols as a bioorthogonal approach to detect fluxes of this important ROS in living systems.
Journal ArticleDOI
Chemical Biology of H2S Signaling through Persulfidation.
TL;DR: The biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation are discussed and the roles ascribed to protein persulfidation in cell signaling pathways are discussed.
Book ChapterDOI
Effective Molarities for Intramolecular Reactions
TL;DR: Mechanistic studies of intramolecular reactions play an important part in elucidating the chemistry of the groups involved in enzyme catalysis and in defining the mechanisms available for particular reactions.