Journal ArticleDOI
Regional bioelectric properties of porcine airway epithelium.
TLDR
In bronchioles, hyperpolarization by luminal Cl(-)-free solution was inversely related to fractional inhibition of PD with amiloride but directly related to lumen diameter, which suggests that porcine tracheas, bronchi, and bron chioles actively absorb Na+, and secretion of Cl- may occur in all airway regions except small bronchiola.Abstract:
Ion transport properties of pulmonary small airway epithelia are poorly understood. To characterize these properties, airways were excised from anesthetized pigs. Transepithelial potential differen...read more
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Journal ArticleDOI
Lung epithelial fluid transport and the resolution of pulmonary edema.
TL;DR: There is convincing evidence that active sodium and chloride transporters are expressed in the distal lung epithelium and are responsible for the ability of the lung to remove alveolar fluid at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema.
Journal ArticleDOI
Salt and water transport across alveolar and distal airway epithelia in the adult lung.
TL;DR: Measurements of osmotic water permeability in in situ perfused lung and isolated perfused airways suggest a significant contribution of these molecular water channels to measuredWater permeability, however, further studies are required to determine the role of these water channels in normal pulmonary physiology and disease.
Journal ArticleDOI
Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects.
Michael R. Knowles,Joseph M. Robinson,Robert E. Wood,Charles A. Pue,William M. Mentz,Gilbert C. Wager,John T. Gatzy,Richard C. Boucher +7 more
TL;DR: It is concluded that there are no significant differences in ASL ion concentrations between CF, normal, and chronic bronchitis subjects and, because ASL ions exceed values consistent with defensin activity, the failure of CF lung defense may reflect predominantly factors other than salt-dependent defensins.
Journal ArticleDOI
The porcine lung as a potential model for cystic fibrosis.
Christopher S. Rogers,William M. Abraham,Kim A. Brogden,John F. Engelhardt,John T. Fisher,Paul B. McCray,Geoffrey McLennan,David K. Meyerholz,Eman Namati,Lynda S. Ostedgaard,Randall S. Prather,Juan R. Sabater,David A. Stoltz,Joseph Zabner,Michael J. Welsh +14 more
TL;DR: In this paper, the authors reviewed aspects of porcine airways and lung that are relevant to CF and found that pigs with a targeted CFTR gene might provide a good model for CF.
Journal ArticleDOI
Novel Role for CFTR in Fluid Absorption from the Distal Airspaces of the Lung
Xiaohui Fang,Norimasa Fukuda,Pascal Barbry,Claudio Sartori,Alan S. Verkman,Michael A. Matthay +5 more
TL;DR: Direct evidence is provided for a functionally important role for CFTR in the distal airspaces of the lung in response to cAMP stimulation by isoproterenol and independent evidence for involvement ofCFTR in cAMP-stimulated Cl− transport is provided.