Journal ArticleDOI
Regioselective Synthesis of Thieno[3,2-c][1]benzopyran-4-ones by Thio-Claisen Rearrangement
Krishna C. Majumdar,A. Biswas +1 more
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TLDR
In this paper, thermal thio-Claisen rearrangement of 4-allylthio[1]benzopyran-2-ones in refluxing quinoline for 0.5-8.0 h was performed.Abstract:
A number of thieno[3,2-c][1]benzopyran-4-ones, potential antiinflamatory, antipyretic, and antiallergic drugs, are synthesized in 65–80% yield by thermal thio-Claisen rearrangement of 4-allylthio[1]benzopyran-2-ones in refluxing quinoline for 0.5–8.0 h. The 4-allylthio[1]benzopyran-2-ones are in turn prepared in 75–85% yield from 4-mercaptocoumarin and different allylic halides by phase-transfer-catalysed alkylation with TBAB or BTEAC catalyst in chloroform-aq. NaOH at room temperature.read more
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Synthesis and evaluation of chromene-based compounds containing pyrazole moiety as antimicrobial agents
TL;DR: 20 hybrid compounds synthesized with an intention to synergize the antimicrobial activity of 1,3-diphenyl pyrazole and chromene derivatives show reasonable antibacterial and antifungal activity.
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Insight on Mercapto-Coumarins: Synthesis and Reactivity
TL;DR: A review of the application of various forms of mercapto-coumarins and their representations in pharmaceuticals and industries can be found in this article , covering the literature issued from 1970 to 2021.
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BTEAC Catalyzed Ultrasonic-Assisted Synthesis of Bromobenzofuran-Oxadiazoles: Unravelling Anti-HepG-2 Cancer Therapeutic Potential through In Vitro and In Silico Studies
Alibay Irfan,Ameer Fawad Zahoor,Azhar Rasul,Sami A. Al-Hussain,Shah Faisal,Sajjad Ahmad,Rida Noor,Muhammed Tilahun Muhammed,Magdi E. A. Zaki +8 more
TL;DR: In this paper , a phase transfer catalyst was used to improve the synthesis of S-alkylated bromobenzofuran-oxadiazole scaffolds BF1-9.
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Journal ArticleDOI
Regioselective Synthesis of Thieno[3,2- c ][1]benzopyran-4-ones by Thio- Claisen Rearrangement
Krishna C. Majumdar,A. Biswas +1 more
TL;DR: In this paper, thermal thio-Claisen rearrangement of 4-allylthio[1]benzopyran-2-ones in refluxing quinoline for 0.5-8.0 h was performed.